CurrentAnesthesia — Haemodynamics, fluids & transfusion

Tranexamic acid and blood loss in pancreaticoduodenectomy: TAC-PD randomized clinical trial

2026-10-28T04:50:19.556Z

Randomised controlled trial · Br J Surg, 2022. Intraoperative blood loss: TXA mean 659 ml · Placebo mean 701 ml

Should Cell Salvage Be Used in Liver Resection and Transplantation? A Systematic Review and Meta-analysis

2026-10-28T04:46:28.518Z

Meta-analysis · Ann Surg, 2022. Allogeneic RBC transfusion, liver transplant — IBSA vs Control: mean difference -1.81 (95% CI -3.22, -0.40); P =0.01; I 2 =86%, very-low certainty

Transfusion-free Strategies in Liver and Pancreatic Surgery: A Predictive Model of Blood Conservation for Transfusion Avoidance in Mainstream Populations

2026-10-28T04:46:28.518Z

Cohort study · Ann Surg, 2022. Perioperative outcomes of transfusion-free liver and pancreatic resections: Liver 7.0%; Clavien grade ≥3 morbidity 7.0% · Pancreas 15.9%; Clavien grade ≥3 morbidity 15.9%

The time cost of physiologically ineffective intravenous fluids in the emergency department: an observational pilot study employing wearable Doppler ultrasound

2026-10-28T04:36:50.728Z

Cohort study · J Intensive Care, 2023. Time spent providing ineffective IV fluid: Total hours across all 51 patients spent providing ineffective IV fluid 29.75

Echocardiographic assessment of pulmonary capillary wedge pressure by E/e' ratio: A systematic review and meta-analysis

2026-10-28T04:33:02.462Z

Meta-analysis · J Crit Care, 2023. Correlation between E/e' and PCWP: Weighted average correlation (r), pooled analysis: modest correlation between E/e' and PCWP 0.43 (95% CI 0.37-0.48)

Physiological and linical ffects of ifferent nfusion ates of ntravenous luids for olume xpansion: A coping eview

2026-10-28T04:33:02.462Z

Research article · J Crit Care, 2023. Physiological and clinical effects: Slower infusion: lower mortality (studies) 2

Association Between Length of Storage of Transfused Packed RBC Units and Outcome of Surgical Critically Ill Adults: A Subgroup Analysis of the Age of Blood Evaluation Randomized Trial*

2026-10-28T04:21:38.918Z

Secondary analysis · Crit Care Med, 2022. All-cause mortality, 90 days: Fresh 29.7% · Standard 28.4%

Disparities in Unilateral Do Not Resuscitate Order Use During the COVID-19 Pandemic*

2026-10-28T04:21:38.918Z

Cross-sectional study · Crit Care Med, 2023. unilateral do-not-resuscitate (UDNR) order use: DNR orders placed 41% (n = 604/1,473)

Lower Versus Higher Exposure to Vasopressor Therapy in Vasodilatory Hypotension: A Systematic Review With Meta-Analysis*

2026-10-28T04:21:38.918Z

Meta-analysis · Crit Care Med, 2022. All-cause mortality, 90 days — Lower exposure vs Higher exposure: RR 0.94 (95% CI 0.87-1.02); moderate certainty, lowered for imprecision

Mean Arterial Pressure Targets and Patient-Important Outcomes in Critically Ill Adults: A Systematic Review and Meta-Analysis of Randomized Trials*

2026-10-28T04:21:38.918Z

Meta-analysis · Crit Care Med, 2022. Mortality — Higher MAP vs Lower MAP: RR 1.06 (95% CI 0.98-1.15); p = 0.12; I2 = 0%

Comparison of clinical outcomes between aggressive and non-aggressive intravenous hydration for acute pancreatitis: a systematic review and meta-analysis

2026-10-28T04:14:48.087Z

Meta-analysis · Crit Care, 2023. All-cause mortality — Aggressive vs Non-aggressive: pooled RR 2.45 (95% CI 1.37, 4.40); severe AP

Fluid balance control in critically ill patients: results from POINCARE-2 stepped wedge cluster-randomized trial

2026-10-28T04:14:48.087Z

Randomised controlled trial · Crit Care, 2023. All-cause mortality, 60 days: Strategy 129 (30.5% (95% CI 26.2-34.8)) · Control 160 (33.9% (95% CI 29.6-38.2))

Point-of-care diagnosis and monitoring of fibrinolysis resistance in the critically ill: results from a feasibility study

2026-10-28T04:14:48.087Z

Cohort study · Crit Care, 2023. Ex vivo response to supplementation (TPA-test lysis time): Distinct response groups: increased fibrinolysis after supplementation with (i) t-PA only or (ii) plasminogen and t-PA

A novel smartphone app for blood pressure measurement: a proof-of-concept study against an arterial catheter

2026-10-28T04:08:44.882Z

Research article · J Clin Monit Comput, 2022. Agreement of app vs invasive BP — OptiBP vs Invasive BP: bias ± SD 0.0 ± 7.5 mmHg (95% limits of agreement CI - 14.9, 14.8); SBP

Does the age of packed red blood cells, donor sex or sex mismatch affect the sublingual microcirculation in critically ill intensive care unit patients? A secondary interpretation of a retrospective analysis

2026-10-28T04:08:44.882Z

Secondary analysis · J Clin Monit Comput, 2022. ∆PPV: Fresh Mean + 8.8% (IQR - 0.5 to 22.5) · Medium Mean 5.5% (IQR 0.1 to 10.1) · Old Mean + 4.7% (IQR - 2.1 to 6.5)

Echocardiographic hemodynamic assessment in decompensated cirrhosis: comparison between Intensivists and Gastroenterologists

2026-10-28T04:08:44.882Z

Cohort study · J Clin Monit Comput, 2023. Inter-rater agreement and reliability: Limits of agreement, subaortic VTI - 6.6 to 7.2 cm

Interaction Between Platelet and Fibrinogen on Clot Strength in Healthy Patients

2026-10-28T03:56:35.329Z

Cohort study · J Cardiothorac Vasc Anesth, 2023. PLT vs thromboelastography maximum amplitude (TEG-MA): Correlation PLT and TEG-MA (univariate), r 0.88; p < 0.0001

Prognostic Model for Vasopressor Requirement After Retroperitoneal Adrenalectomy for Pheochromocytoma: A Retrospective Study

2026-10-28T03:56:35.329Z

Cohort study · J Cardiothorac Vasc Anesth, 2023. Postoperative vasopressor requirement — Baseline coronary artery disease (CAD): OR 6.21 (95% CI 2.48-15.52); p = 0.0001

Mesenteric traction syndrome — Incidence, impact, and treatment: A systematic scoping review of the literature

2026-10-28T03:54:35.559Z

Research article · Anaesth Crit Care Pain Med, 2022. Combined incidence of MTS during open abdominal surgery: MTS incidence 76%

Haemoglobin levels and outcomes of subgroups of patients with pre‐operative anaemia based on red cell size: A retrospective cohort study

2026-10-28T03:44:37.230Z

Cohort study · Acta Anaesthesiol Scand, 2023. Pre-operative anaemia subgroups by red cell size: Microcytic 1089 (10.4%) · Normocytic 9243 (88.0%) · Macrocytic 173 (1.6%)

Intra‐operative blood transfusion in elderly patients on antithrombotic therapy

2026-10-28T03:44:37.230Z

Secondary analysis · Acta Anaesthesiol Scand, 2023. Intra-operative transfusion of packed RBC: Antithrombotic therapy 191 (4.7%) · No antithrombotic therapy 98 (3.2%)

Issuing of isotonic crystalloid solutions to Danish public hospitals in 2021—A retrospective nationwide observational study

2026-10-28T03:44:37.230Z

Cohort study · Acta Anaesthesiol Scand, 2022. Isotonic crystalloid solutions issued nationally, 2021: Total issued 1,487,144 L

Use of vasoactive agents in non‐cardiac surgery: Protocol for a scoping review

2026-10-28T03:44:37.230Z

Research article · Acta Anaesthesiol Scand, 2022. Planned overview of indications, agents used and outcomes assessed for vasoactive agents in non-cardiac surgery

Viscoelastic versus conventional coagulation tests to reduce blood product transfusion in patients undergoing liver transplantation: A systematic review and meta-analysis

2026-10-28T03:35:32.861Z

Meta-analysis · Eur J Anaesthesiol, 2022. Transfused units per blood product — VETs vs CCTs: mean difference -1.40 RBC units (95% CI -1.87 to -0.92); P < 0.001; I2 = 61%

Improving Patient Blood Management Programs: An Implementation Science Approach

2026-10-28T03:28:59.708Z

Research article · Anesth Analg, 2022. Practical implementation guidance on key clinical, administrative, leadership and structural elements for safe, comprehensive delivery of care in PBM programs at the local level

Incidence of Postreperfusion Hyperfibrinolysis in Liver Transplantation by Donor Type and Observed Treatment Strategies

2026-10-28T03:28:59.708Z

Cohort study · Anesth Analg, 2022. Hyperfibrinolysis after reperfusion: DBD 16 (3.1%) · DCD 5 (27.8%) · Living donors 0 (0.0%)

The association between iron deficiency and outcomes: a secondary analysis of the intravenous iron therapy to treat iron deficiency anaemia in patients undergoing major abdominal surgery ( PREVENTT ) trial

2026-10-28T03:25:23.999Z

Secondary analysis · Anaesthesia, 2022. Blood transfusion or death and number of blood transfusions, by baseline iron status subgroup, 30 days: IV iron vs placebo did not differentially reduce death or blood transfusion across subgroups by ferritin (interaction P) p = 0.33

Effect of pneumatic leg compression on post‐induction hypotension in elderly patients undergoing robot‐assisted laparoscopic prostatectomy: a double‐blind randomised controlled trial

2026-10-28T03:25:23.999Z

Randomised controlled trial · Anaesthesia, 2023. Incidence of post-induction hypotension (SBP < 90 mmHg during the first 20 min after induction), first 20 min after induction: Pneumatic leg compression 5 (10%) · Control 29 (58%)

The safety of tranexamic acid administration in total knee arthroplasty: a population‐based study from Taiwan

2026-10-28T03:25:23.999Z

Cohort study · Anaesthesia, 2022. Blood transfusion — TXA vs No TXA: RR 0.50 (95% CI 0.48-0.51); 50% decrease

Endotypes of intraoperative hypotension during major abdominal surgery: a retrospective machine learning analysis of an observational cohort study

2026-10-28T03:18:44.786Z

Secondary analysis · Br J Anaesth, 2022. Intraoperative hypotension endotypes: Episodes of intraoperative hypotension 615

Recommendations From the International Consensus Conference on Anemia Management in Surgical Patients (ICCAMS)

2026-10-27T23:40:12.801Z

Guideline or statement · Ann Surg, 2022.

Balanced crystalloid solution versus saline in deceased donor kidney transplantation (BEST-Fluids): a pragmatic, double-blind, randomised, controlled trial

2026-10-27T23:36:21.661Z

Randomised controlled trial · Lancet, 2023. DGF: Balanced crystalloid 121 (30%) · Saline 160 (40%)

Platelet Transfusion before CVC Placement in Patients with Thrombocytopenia

2026-10-27T23:35:39.811Z

Randomised controlled trial · N Engl J Med, 2023. Catheter-related bleeding of grade 2 to 4: Transfusion 9 (4.8%) · No transfusion 22 (11.9%)

Tranexamic Acid vs Adrenaline for Controlling Iatrogenic Bleeding During Flexible Bronchoscopy: A Double-Blind Randomized Controlled Trial

2026-10-27T23:33:56.230Z

Randomised controlled trial · Chest, 2022. Bleeding stopped: Adrenaline 54 (83.1%) · TXA 54 (83.1%)

Optimal dosing of heparin for prophylactic anticoagulation in critically ill COVID-19 patients a systematic review and meta-analysis of randomized controlled trials

2026-10-27T23:28:00.394Z

Meta-analysis · J Crit Care, 2023. Mortality — Escalated dose vs Standard thromboprophylaxis: RR 1.01 (95% CI 0.90-1.13); no significant impact

Right ventricular echocardiographic parameters and prediction of stroke volume in ischemic cardiogenic shock: A retrospective study

2026-10-27T23:28:00.394Z

Cohort study · J Crit Care, 2022. Correlation with SV: RVOT VTI correlated best to SV r = 0.39 p = 0.01

Advances in the Management of Cardiogenic Shock

2026-10-27T23:20:28.165Z

Research article · Crit Care Med, 2023. CS results in short-term mortality exceeding 30% despite standard therapy

Angiotensin II for the Treatment of Refractory Shock: A Matched Analysis*

2026-10-27T23:20:28.165Z

Cohort study · Crit Care Med, 2023. 30-day mortality, 30 days: Angiotensin II 60% · Control 56%

Noninvasive Monitoring of Arterial Pressure: Finger or Lower Leg As Alternatives to the Upper Arm: A Prospective Study in Three ICUs

2026-10-27T23:20:28.165Z

Cohort study · Crit Care Med, 2023. Agreement for mean AP (bias): Lower leg bias 6.0 ± 15.8 mm Hg · Upper bias 3.6 ± 7.1 mm Hg · Finger bias 0.1 ± 7.4 mm Hg

Sodium Bicarbonate for Metabolic Acidosis in the ICU: Results of a Pilot Randomized Double-Blind Clinical Trial

2026-10-27T23:20:28.165Z

Randomised controlled trial · Crit Care Med, 2023. Hours alive and free of vasopressor, day 7: Sodium bicarbonate median 132.2 (IQR 85.6-139.1) hours · Placebo median 97.1 (IQR 69.3-132.4) hours

Correlation between the VExUS score and right atrial pressure: a pilot prospective observational study

2026-10-27T23:14:23.345Z

Cohort study · Crit Care, 2023. Association between RAP and VExUS grade: Significant positive association between RAP and VExUS grade (adjusted for age, sex, common comorbidities), P < 0.001 R2 = .68

Diagnostic accuracy of point-of-care ultrasound for shock: a systematic review and meta-analysis

2026-10-27T23:14:23.345Z

Meta-analysis · Crit Care, 2023. Pooled sensitivity and specificity (95% CI): Obstructive shock: sensitivity 0.82 (0.68-0.91); specificity 0.98 (0.92-0.99); positive likelihood ratio 40 (11-105) · Cardiogenic shock: sensitivity 0.78 (0.56-0.91); specificity 0.96 (0.92-0.98) · Hypovolemic shock: sensitivity 0.90 (0.84-0.94); specificity 0.92 (0.88-0.95) · Distributive shock: sensitivity 0.79 (0.71-0.85); specificity 0.96 (0.91-0.98)

Initiating angiotensin II at lower vasopressor doses in vasodilatory shock: an exploratory post-hoc analysis of the ATHOS-3 clinical trial

2026-10-27T23:14:23.345Z

Secondary analysis · Crit Care, 2023. 28-day survival, adjusted for severity of illness, by baseline NED subgroup, 28 days: Low-NED subgroup: AT II half as likely to die at 28 days vs placebo

The increase in cardiac output induced by a decrease in positive end-expiratory pressure reliably detects volume responsiveness: the PEEP-test study

2026-10-27T23:14:23.345Z

Diagnostic or prognostic study · Crit Care, 2023. PEEP-test (CI increase > 8.6%) for detecting volume responsiveness: PEEP-test: sensitivity 96.8% (95%CI: 83.3-99.9%); specificity 84.9% (95%CI 68.1-94.9%); AUC 0.94 (95%CI 0.85-0.98) (p < 0.0001 vs. 0.5)

Variation in central venous oxygen saturation to evaluate fluid responsiveness: a systematic review and meta-analysis

2026-10-27T23:14:23.345Z

Meta-analysis · Crit Care, 2023. Diagnostic performance for fluid responsiveness: ΔScvO2: AUHSROC 0.86 (95% CI 0.83-0.89); pooled sensitivity 0.78 (95% CI 0.69-0.85); pooled specificity 0.84 (95% CI 0.72-0.91); pooled diagnostic OR 17.7 (95% CI 5.9-53.2)

Direct assessment of microcirculation in shock: a randomized-controlled multicenter study

2026-10-27T23:13:02.241Z

Randomised controlled trial · Intensive Care Med, 2023. 30-day mortality, 30 days: 30-day mortality did not differ

Bioimpedance based determination of cardiac index does not show enough trueness for point of care use in patients with systolic heart failure

2026-10-27T23:08:04.173Z

Cohort study · J Clin Monit Comput, 2023. CO agreement, TBI vs thermodilution (all patients): Mean bias for CO 0.3 L/min

Blood pressure control with phenylephrine or dobutamine: a randomized controlled trial comparing effects on cerebral and paravertebral tissue oxygen saturation measured with near-infrared spectroscopy

2026-10-27T23:08:04.173Z

Randomised controlled trial · J Clin Monit Comput, 2023. Paravertebral tissue saturation (rSpvO2): No significant changes at the paravertebral level in either group; slight but statistically significant difference between groups at T3-T4 and L1-L2

Carotid flow as a surrogate of the left ventricular stroke volume

2026-10-27T23:08:04.173Z

Cohort study · J Clin Monit Comput, 2022. Agreement of carotid VTI with LVOT VTI — CS VTI vs LVOT VTI: Spearman's correlation coefficient 0.81 (95% CI 0.67-0.89)

Diuretics depletion improves cardiac output and ventriculo-arterial coupling in congestive ICU patients during hemodynamic de-escalation

2026-10-27T23:08:04.173Z

Cohort study · J Clin Monit Comput, 2023. Cardiac index after vs before diuretics, 24 h: Congestive mean 2.7 ± 0.8 L min- 1 m- 2; baseline 2.5 ± 0.8 L min- 1 m- 2; P vs baseline p = 0.042 · Non-congestive mean 2.7 ± 0.7 L min- 1 m- 2; baseline 2.7 ± 0.8 L min- 1 m- 2; P vs baseline p = 0.968