CurrentAnesthesia — Trauma & major bleeding

Association Between Hemorrhage Control Interventions and Mortality in US Trauma Patients With Hemodynamically Unstable Pelvic Fractures

2026-10-28T04:49:16.800Z

Cohort study · JAMA Surg, 2023. Mortality — Pelvic AE: OR 0.62 (95% CI 0.47 to 0.82); P < .001; regression analysis; only pelvic AE associated with mortality reduction

Zone 1 Endovascular Balloon Occlusion of the Aorta vs Resuscitative Thoracotomy for Patient Resuscitation After Severe Hemorrhagic Shock

2026-10-28T04:49:16.800Z

Cohort study · JAMA Surg, 2023. Mortality: REBOA 44 (78.6%) · RT 52 (92.9%)

Association Between Blood Donor Demographics and Post-injury Multiple Organ Failure after Polytrauma

2026-10-28T04:46:28.518Z

Cohort study · Ann Surg, 2021. MOF by donor sex and age: Donor-recipient sex mismatched RBC transfusions more likely associated with MOF P = 0.0012

Burn Resuscitation Practices in North America: Results of the Acute Burn ResUscitation Multicenter Prospective Trial (ABRUPT)

2026-10-28T04:46:28.518Z

Cohort study · Ann Surg, 2021. Total fluid received, 24 hours: Albumin mean 5.2 ± 2.3 mL/kg/% TBSA burn/24 hours · Crystalloid mean 3.7 ± 1.7 mL/kg/% TBSA burn/24 hours

Direct Trauma Center Access by Helicopter Emergency Medical Services is Associated With Improved Survival After Severe Injury

2026-10-28T04:46:28.518Z

Cohort study · Ann Surg, 2023. Survival — Direct helicopter vs NTC ground + transfer: aOR for survival 2.78 (95% CI 2.24-3.44); P <0.01; described as a nearly 2-fold increase in odds of survival

Optimizing Trauma Systems: A Geospatial Analysis of the Victorian State Trauma System

2026-10-28T04:46:28.518Z

Cohort study · Ann Surg, 2023. Transport directly to a major trauma service (MTS): Transported directly to an MTS (all patients, observed) 58%

The Golden Hour of Casualty Care: Rapid Handoff to Surgical Team is Associated With Improved Survival in War-injured US Service Members

2026-10-28T04:46:28.518Z

Cohort study · Ann Surg, 2023. 24-hour mortality, 24 hours — Handoff within 1 hour vs Delayed surgical care: aHR 0.34 (95% CI 0.14-0.82); P = 0.02; handoff alive to the surgical team

Use of Bayesian Statistics to Reanalyze Data From the Pragmatic Randomized Optimal Platelet and Plasma Ratios Trial

2026-10-28T04:44:26.953Z

Secondary analysis · JAMA Netw Open, 2023. Mortality, bayesian analysis — 1:1:1 vs 1:1:2: RR 0.75 (95% CrI 0.45-1.11); 24-hour mortality; 95% CrI; Bayes factor 13.7; 93% probability of superiority

Aspirin or Low-Molecular-Weight Heparin for Thromboprophylaxis after a Fracture

2026-10-28T04:42:32.209Z

Randomised controlled trial · N Engl J Med, 2023. Death from any cause, 90 days: Aspirin 47 (0.78%) · Low-molecular-weight heparin 45 (0.73%)

Prehospital tranexamic acid for trauma victims

2026-10-28T04:36:50.728Z

Research article · J Intensive Care, 2023. UK paramedics now authorized to give IM TXA prehospital

Catabolism highly influences ICU-acquired hypernatremia in a mainly trauma and surgical cohort

2026-10-28T04:33:02.462Z

Cohort study · J Crit Care, 2023. ICU-acquired hypernatremia: Developed ICU-acquired hypernatremia 377 (38%)

Hemorrhage, Disseminated Intravascular Coagulopathy, and Thrombosis Complications Among Critically Ill Patients with COVID-19: An International COVID-19 Critical Care Consortium Study*

2026-10-28T04:21:38.918Z

Cohort study · Crit Care Med, 2023. Prevalence of HECTOR complications: Any HECTOR complication (1,732/11,969) 14%

Association of red blood cells and plasma transfusion versus red blood cell transfusion only with survival for treatment of major traumatic hemorrhage in prehospital setting in England: a multicenter study

2026-10-28T04:14:48.087Z

Cohort study · Crit Care, 2023. Death, 24-h — RCP vs RBC: aOR 0.69 (95% CI 0.52; 0.92)

Shock index as predictor of massive transfusion and mortality in patients with trauma: a systematic review and meta-analysis

2026-10-28T04:14:48.087Z

Meta-analysis · Crit Care, 2023. MT prediction: SI: sensitivity 0.68 [0.57; 0.76]; specificity 0.84 [0.79; 0.88]; AUC 0.85 [0.81; 0.88]; LR+ 4.24 [3.18-5.65]; LR- 0.39 [0.29-0.52]

The European guideline on management of major bleeding and coagulopathy following trauma: sixth edition

2026-10-28T04:14:48.087Z

Guideline or statement · Crit Care, 2023.

Comparing restrictive versus liberal oxygen strategies for trauma patients: The TRAUMOX2 trial—Statistical analysis plan

2026-10-28T03:44:37.230Z

Trial design · Acta Anaesthesiol Scand, 2023. Composite of 30-day mortality and/or major respiratory complications (pneumonia and/or ARDS), 30 days

Thromboembolic and bleeding events in ICU patients with COVID‐19: A nationwide, observational study

2026-10-28T03:44:37.230Z

Cohort study · Acta Anaesthesiol Scand, 2022. Thromboembolic and bleeding events in ICU: Thromboembolic event, n % 158 (12%) (95% CI 10-13)

Cognitive aids in the management of clinical emergencies: a systematic review

2026-10-28T03:25:23.999Z

Meta-analysis · Anaesthesia, 2022. Missed care steps: Cognitive aids 11% · Usual care 43.3%

Association of Whole Blood With Survival Among Patients Presenting With Severe Hemorrhage in US and Canadian Adult Civilian Trauma Centers

2026-10-27T23:42:42.982Z

Cohort study · JAMA Surg, 2023. Mortality, 24 hours — WB-MTP vs MTP-only: HR 0.63 (95% CI 0.41-0.96); P = .03; 37% lower risk of mortality

Clinical Practice Guideline Recommendations For Pediatric Multisystem Trauma Care: A Systematic Review

2026-10-27T23:40:12.801Z

Meta-analysis · Ann Surg, 2023. Number, strength and evidence quality of CPG recommendations for pediatric multisystem trauma: CPGs reviewed 19

Low Titer Group O Whole Blood In Injured Children Requiring Massive Transfusion

2026-10-27T23:40:12.801Z

Cohort study · Ann Surg, 2021. 28-day survival, 28 days — LTOWB vs CT: aOR 0.41, event not clearly stated; P = 0.02; significantly improved survival with LTOWB; adjusted for age, total blood product volume in 24 h, admission base deficit, international normalized ratio (INR), injury severity score (ISS)

Single-nuclei RNA Profiling Reveals Disruption of Adipokine and Inflammatory Signaling in Adipose Tissue of Burn Patients

2026-10-27T23:40:12.801Z

Cohort study · Ann Surg, 2023. Systemic inflammation and adrenergic stress increase IL-6 signaling, lipolysis, browning and adipokine dysfunction in adipose tissue of adult burn patients

Comparison of Injuries Associated With Electric Scooters, Motorbikes, and Bicycles in France, 2019-2022

2026-10-27T23:37:19.358Z

Cohort study · JAMA Netw Open, 2023. ISS of 16 or higher: E-scooter 102 (45.5%) · Motorbike 1557 (39.7%) · Bicycle 411 (47.3%)

Effect of Dexmedetomidine on Posttraumatic Stress Disorder in Patients Undergoing Emergency Trauma Surgery: A Randomized Clinical Trial

2026-10-27T23:37:19.358Z

Randomised controlled trial · JAMA Netw Open, 2023. Incidence of PTSD, 1 month postoperatively: Dexmedetomidine 14.1% · Normal saline 24.0%

Efficacy and Safety of Early Administration of 4-Factor Prothrombin Complex Concentrate in Patients With Trauma at Risk of Massive Transfusion: The PROCOAG Randomized Clinical Trial

2026-10-27T23:36:43.961Z

Randomised controlled trial · JAMA, 2023. Total 24-hour blood product consumption, 24 hours: 4F-PCC median 12 (IQR 5-19) U · Placebo median 11 (IQR 6-19) U

Prehospital Tranexamic Acid for Severe Trauma

2026-10-27T23:35:39.811Z

Randomised controlled trial · N Engl J Med, 2023. Survival with a favorable functional outcome (GOS-E level ≥5), 6 months: Tranexamic acid 307 (53.7%) · Placebo 299 (53.5%)

Coagulopathy correlates with muscle titin injury in critically ill patients

2026-10-27T23:28:00.394Z

Secondary analysis · J Crit Care, 2022. Mean N-titin/Cre: Mean N-titin/Cre significantly higher in the JAAM-DIC group

Saudi Critical Care Society clinical practice guidelines on the prevention of venous thromboembolism in adults with trauma: reviewed for evidence-based integrity and endorsed by the Scandinavian Society of Anaesthesiology and Intensive Care Medicine

2026-10-27T23:25:45.237Z

Guideline or statement · Ann Intensive Care, 2023.

The Efficacy of Glutamine Supplementation in Severe Adult Burn Patients: A Systematic Review With Trial Sequential Meta-Analysis

2026-10-27T23:20:28.165Z

Meta-analysis · Crit Care Med, 2023. Overall mortality — Glutamine vs Control: RR 0.65 (95% CI 0.33-1.28); p = 0.21

Early non-invasive ventilation and high-flow nasal oxygen therapy for preventing endotracheal intubation in hypoxemic blunt chest trauma patients: the OptiTHO randomized trial

2026-10-27T23:14:23.345Z

Randomised controlled trial · Crit Care, 2023. Endotracheal intubation for delayed respiratory failure: Experimental 5 (7%) · Control 6 (8.6%)

Thromboelastometry-guided haemostatic resuscitation in severely injured patients: a propensity score-matched study

2026-10-27T23:14:23.345Z

Cohort study · Crit Care, 2023. Proportion alive and free of massive transfusion (MT), 24 h after injury: VHA 162 (75%) · CCT 112 (52%)

Comprehensive analysis of coagulation factor delivery strategies in a cohort of trauma patients

2026-10-27T22:55:35.298Z

Cohort study · Anaesth Crit Care Pain Med, 2022. Coagulation factor administration within first 24 hours: SH 93%; Fibrinogen concentrate (FC) 75% · MT 99%; FC 92%

Continuous peripheral nerve blocks for analgesia of ventilated critically ill patients with multiple trauma: a prospective randomized study

2026-10-27T22:55:35.298Z

Randomised controlled trial · Anaesth Crit Care Pain Med, 2022. Cumulative sufentanil consumption, 48h — CRA vs Control; p = 0.16; no significant difference

Injury outcomes across Canadian trauma systems: a historical cohort study

2026-10-27T22:52:26.060Z

Cohort study · Can J Anaesth, 2023. Patient case mix, case volumes, and risk-adjusted outcomes (mortality, ICU admission, hospital and ICU LOS): Patient distributions in level I and II TCs similar across provinces; significant differences in case mix and volumes for level III TCs

Saudi Critical Care Society clinical practice guidelines on the prevention of venous thromboembolism in adults with trauma: Endorsement by the Scandinavian Society of Anaesthesiology and Intensive Care Medicine

2026-10-27T22:48:29.585Z

Guideline or statement · Acta Anaesthesiol Scand, 2023.

Prevalence of preoperative metabolic disturbances in elderly patients with hip fracture and their association with mortality – A retrospective cohort study

2026-10-27T22:44:42.780Z

Cohort study · J Clin Anesth, 2023. 90-day mortality: Both acidosis and lactatemia 19.1% · Neither 4.4%

The first hour of trauma reception is critical for patients with major thoracic trauma: A retrospective analysis from the TraumaRegister DGU

2026-10-27T22:41:13.584Z

Cohort study · Eur J Anaesthesiol, 2023. Mortality: Mortality in major thoracic trauma 5.9%

Association Between Profound Shock Signs and Peripheral Intravenous Access Success Rates in Trauma Patients in the Prehospital Scenario: A Retrospective Study

2026-10-27T22:35:32.011Z

Cohort study · Anesth Analg, 2023. Number of attempts required for first IV access success (ordinal: 1, 2, 3 and higher, ultimate failure): Profound shock 67.8%; first attempt 67.8%; second attempt 16.7%; third and further attempts 5.6%; unsuccessful attempts 10% · Nonshock 80.8%; first attempt 80.8%; second attempt 9.4%; third and further attempts 3.8%; unsuccessful attempts 6%

Association of Opioid Administration During General Anesthesia and Survival for Severely Injured Trauma Patients: A Preplanned Secondary Analysis of the PROPPR Study

2026-10-27T22:35:32.011Z

Secondary analysis · Anesth Analg, 2023. Mortality, any opioid vs none — Opioid dose groups vs No opioid: OR 0.02-0.04 (CI 0.003-0.1); P < .001; 6 hours; adjusted

In Vitro Analysis of Platelet Adhesion, Aggregation, and Surface GP1bα Expression in Stored Refrigerated Whole Blood: A Pilot Study

2026-10-27T22:35:32.011Z

Mechanistic study · Anesth Analg, 2023. Platelet adhesion and aggregation under high shear (PFA-100 adenosine diphosphate (ADP)/collagen closure time): Timepoint 1 mean 208.7 (+ 91.5) seconds · Timepoint 3 mean 390.0 (+ 148.3) seconds

Narrative Review: Is There a Transfusion Cutoff Value After Which Nonsurvivability Is Inevitable in Trauma Patients Receiving Ultramassive Transfusion?

2026-10-27T22:35:32.011Z

Research article · Anesth Analg, 2023. Effects of UMT on outcomes including survival; whether a threshold transfusion limit exists after which mortality is inevitable: Data on utility of UMT in trauma of poor quality; no universally accepted transfusion cutoff exists

Study of the Relationship Between Liver Function Markers and Traumatic Rhabdomyolysis: A Retrospective Study of Hemorrhagic Patients Admitted to Intensive Care Unit in a Level I Trauma Center

2026-10-27T22:35:32.011Z

Cohort study · Anesth Analg, 2023. Correlation of log-CK with liver biomarkers; liver failure: Intense RM 18.2% · No intense RM 4.6%

Ultramassive Transfusion for Trauma in the Age of Hemostatic Resuscitation: A Retrospective Single-Center Cohort From a Large US Level-1 Trauma Center, 2011–2021

2026-10-27T22:35:32.011Z

Cohort study · Anesth Analg, 2023. Overall mortality: Overall mortality 65% (n = 103)

Association of Trauma Molecular Endotypes With Differential Response to Transfusion Resuscitation Strategies

2026-10-27T18:57:44.465Z

Secondary analysis · JAMA Surg, 2023. 30-day mortality by endotype and transfusion strategy (subgroup), 30 days: TE-1 mortality with 1:1:2 28.6%

Association of Trauma With Long-Term Risk of Death and Immune-Mediated or Cancer Disease in Same-Sex Twins

2026-10-27T18:57:44.465Z

Cohort study · JAMA Surg, 2023. Composite of death or immune-mediated or cancer disease: Trauma 724 (32%) · Co-twin 544 (24%)

Potential Avoidable Costs of Low-Value Clinical Practices in Acute Injury Care in an Integrated Canadian Provincial Trauma System

2026-10-27T18:57:44.465Z

Research article · JAMA Surg, 2023. Direct health care costs associated with 11 low-value clinical practices

Emergency Department Pediatric Readiness Among US Trauma Centers: A Machine Learning Analysis of Components Associated With Survival

2026-10-27T18:55:07.732Z

Cohort study · Ann Surg, 2022. Change in survival by ED pediatric readiness component: Policy for mental health care +8.8%

Therapeutic Interventions and Outcomes in Civilian and Military Isolated Gunshot Wounds to the Head: A Department of Defense Trauma Registry and ACS TQIP-matched Study

2026-10-27T18:55:07.732Z

Cohort study · Ann Surg, 2022. Mortality: Military 27% · Civilian 38%

The Restrictive Red Blood Cell Transfusion Strategy for Critically Injured Patients (RESTRIC) trial: a cluster-randomized, crossover, non-inferiority multicenter trial of restrictive transfusion in trauma

2026-10-27T18:46:42.182Z

Randomised controlled trial · J Intensive Care, 2023. 28-day survival, 28 days: Restrictive 92.1% · Liberal 91.3%

Resuscitative transesophageal echocardiography during the acute resuscitation of trauma: A retrospective observational study

2026-10-27T18:44:24.801Z

Cohort study · J Crit Care, 2023. Diagnostic yield and management impact of TEE: New diagnosis made 31 (57%)