24-h movement behaviors and the association of chronic pain with venous thromboembolism risk
Authors' conclusion
CP was associated with an increased risk of VTE. In participants with MCP, 24-h movement behaviors showed a potential association that may contribute to this relationship.
Study context
- Population
- UK Biobank participants88,675 accelerometer sub-cohort
- Participants
- 453,289 participants
- Exposure
- Limited or multisite chronic pain vs pain-free
- Outcome
- Incident VTE
Methodological detailspopulation-based, UK Biobank
- Population-based
- UK Biobank
Main finding
As reported in the abstract
Each group vs pain-freeHazard ratio (95% CI)P value
LCP
1.13(1.08–1.19)
P < 0.001MCP
1.32(1.24–1.41)
P < 0.001Observational data: associations, not effects.
Further findings
Venous thromboembolism (VTE) risk with reallocating 1 h/day from sleep (multisite chronic pain (MCP) participants)
| HR (95% CI) | ||
|---|---|---|
| Sleep to LIPAExploratory · hypothetical reallocation models | 0.87 (0.76–0.99) | |
| Sleep to MVPAExploratory · hypothetical reallocation models | 0.59 (0.35–0.98) | |
| 0.20.5125Hazard ratio (log scale) |
Mediation of MCP-VTE association by 24-h movement behaviors (accelerometer sub-cohort)
- Indirect effect HR
- 1.03 [1.01-1.05]
- Total effect HR
- 1.25 [1.02-1.48]
- Proportion mediated
- 12.8%
- Exploratory
Original publication
24-h movement behaviors and the association of chronic pain with venous thromboembolism risk. J Clin Anesth. Published 5 May 2026. doi:10.
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