Perioperative medicine & outcomes
A first assessment of the safe brain initiative care bundle for addressing postoperative delirium in the postanesthesia care unit
Main finding · POD in the PACU per month of SBI-CB implementationResult — go to the resultAdjusted odds ratio 0.96 95% CI 0.94–0.97Authors' conclusion
The presented pragmatic implementation of a multidisciplinary care bundle, encompassing pre-, intra-, and postoperative measures alongside outcome monitoring, has the potential to significantly reduce the incidence of POD in the PACU.
Study context
- Population
- Adults ≥18 years scheduled for surgery who could communicate verbally, 4 hospitals in Denmark and Turkey
- Participants
- 18,697 adults · 4 hospitals
- Exposure
- Implementation of the Safe Brain Initiative care bundle (SBI-CB), per month of implementation
- Outcome
- POD trend in the PACU during implementation months (Nu-DESC screening at up to 3 time points in the PACU)
Methodological detailsmulticentre, pragmatic implementation, adjusted for confounders
- Multicentre
- Pragmatic implementation
- Adjusted for confounders
Main finding
As reported in the abstract
Adjusted odds ratio
0.96
95% CI 0.94–0.97
P < 0.001
Each month of SBI-CB implementation, as printed
Observational data: associations, not effects.
Further findings
Initial postoperative delirium (POD) incidence in the postanesthesia care unit (PACU), all sites · after the first 3 months
- POD incidence (n = 1021)
- 16.36%
Risk factors for POD in the PACU
- GA and longer surgical duration (>1 h) significant risk factors
- POD in all age groups, peak in younger (18-35 years) and older (>75 years) patients
Hospital LOS, matched patients with vs without POD in the PACU
- Mean hospital stay increase from 35 to 69 h with POD (p < 0.001)
- Matched patients
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →