Pediatric anesthesia & critical care
A randomized, double‐blind, dose‐controlled study of the use of dexmedetomidine alone for procedural sedation of children and adolescents undergoing MRI scans
Primary result · Completed MRI without propofol rescueResult — go to the resultOdds ratio 10.29 95% CI 3.47–30.50Authors' conclusion
Dexmedetomidine was well tolerated. The high dose was associated with meaningfully greater efficacy compared with lower doses.
Study context
- Population
- Children ≥1month-<17years undergoing MRI, stratified into Cohort A (≥1month-<2years) and Cohort B (≥2-<17years)
- Participants
- 122 children
- Comparison
- High-dose vs Low-dose
- High-dosen = 38
- Middle-dosen = 42
- Low-dosen = 42reference
- Primary endpoint
- Percentage completing MRI without rescue propofol, high vs low dose
Methodological detailsdouble-blind, dose-ranging, multicentre (USA and Japan), Recruited February 2020 to November 2021
- Double-blind
- Dose-ranging
- Multicentre (USA and Japan)
- Recruited February 2020 to November 2021
Primary result
Completed MRI without propofol rescue
Odds ratio
10.29
95% CI 3.47–30.50
P < 0.001
Events by treatment group
High-dose vs Low-dose
OR 10.29 (95% CI 3.47–30.50); P < 0.001
As reported in the abstract
Secondary outcomes
No propofol required, by age cohort (high vs low dose)
- Similar results in both age cohorts
Safety
Adverse events
- Most common: bradypnea, bradycardia, hypertension, hypotension; majority mild-to-moderate
Original publication
A randomized, double‐blind, dose‐controlled study of the use of dexmedetomidine alone for procedural sedation of children and adolescents undergoing MRI scans. Paediatr Anaesth. Published 16 February 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →