Addition of dexmedetomidine to anesthesia regimen reduces pain level after endoscopic submucosal dissection: A systematic review and meta analysis
Pooled result · Postoperative painResult — go to the resultRelative risk 0.50 95 % CI 0.35–0.70Authors' conclusion
Our updated systematic review and meta-analysis demonstrated a significant difference in the postoperative pain level in the group with concomitant dexmedetomidine and midazolam sedation compared to midazolam alone for the endoscopic dissection of superficial gastrointestinal neoplasias.
Study context
- Population
- Adults with gastrointestinal neoplasias undergoing endoscopic submucosal dissection5 RCTs, 1 observational study
- Participants
- 643 adults
- Comparison
- Dexmedetomidine vs control
- Outcome
- Postoperative pain, sedation time and adverse event rate
Methodological detailsPRISMA, GRADE, Risk of bias low; moderate-to-high quality of evidence
- PRISMA
- GRADE
- Risk of bias low; moderate-to-high quality of evidence
Pooled result
Postoperative pain
Relative risk
0.50
95 % CI 0.35–0.70
P < 0.01
Dexmedetomidine vs Control
RR 0.50 (95 % CI 0.35–0.70); P < 0.01
As reported in the abstract
Further pooled results
Sedation time
- No significant difference between groups (2 RCTs and 1 observational study, 249 patients)
- SMD = 0.27; 95 % CI = [−0.62; 1.17]; p = 0.32
Safety
Adverse event rate
- No significant difference between groups
- RR = 1.04; 95 % CI = [0.55; 1.98]; p = 0.85
Original publication
Addition of dexmedetomidine to anesthesia regimen reduces pain level after endoscopic submucosal dissection: A systematic review and meta analysis. J Clin Anesth. Published 18 November 2025. doi:10.
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