Additive or synergistic analgesic effect of metamizole on standard pain treatment at home after arthroscopic shoulder surgery: A randomised controlled superiority trial
Primary resultResult — go to the resultMean difference −0.08 NRS 95% CI −1.00 to 0.84Authors' conclusion
Clinically, triple oral treatment with metamizole, paracetamol and ibuprofen is not superior to oral paracetamol and ibuprofen in multimodal pain treatment at home after ambulatory arthroscopic shoulder surgery.
Study context
- Population
- Patients undergoing elective ambulatory arthroscopic shoulder surgery
- Participants
- 110 patients
- Comparison
- Metamizole, ibuprofen and paracetamol (MIP) vs i.p.
- MIPn = 55
- i.p.n = 55reference
- Primary endpoint
- Postoperative pain intensity on movement (11-point numeric rating scale (NRS), 0 = no pain, 10 = worst pain imaginable)
- Follow-up
- POD 1
Methodological detailsdouble-blind, superiority, high-volume single centre
- Double-blind
- Superiority
- High-volume single centre
Primary result
As reported in the abstract
Mean difference
−0.08 NRS
95% CI −1.00 to 0.84
MIP vs i.p.
mean difference −0.08 NRS (95% CI −1.00 to 0.84)
Further findings
Pain on movement and at rest, post-anaesthesia care unit (PACU) and postoperative day (POD) 1 to 4 and day 7
- No significant differences between groups
Rescue opioid consumption, perceived pain relief, Quality of Recovery (QoR) at POD 7, overall patient satisfaction
- Similar in both groups
Safety
Nausea
- Reported significantly more frequently in the metamizole group
- 22.6 vs. 58.5; P < 0.001
Other adverse effects of study medication
- Similar in both groups
Original publication
Additive or synergistic analgesic effect of metamizole on standard pain treatment at home after arthroscopic shoulder surgery: A randomised controlled superiority trial. Eur J Anaesthesiol. Published 11 January 2023. doi:10.
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