ICU sedation, delirium & recovery
Advancing Delirium Treatment Trials in Older Adults: Recommendations for Future Trials From the Network for Investigation of Delirium: Unifying Scientists (NIDUS)
Methodological detailsinterprofessional and international expert working group, four expert panels, review of delirium treatment randomized controlled trials (RCTs) 2003–2023, in-person conference
- Interprofessional and international expert working group
- Four expert panels
- Review of delirium treatment RCTs 2003–2023
- In-person conference
Recommendations
As issued by the authors
Design interventions that consider the multifactorial nature of delirium, include both pharmacological and nonpharmacologic approaches, and target pathophysiologic pathways where possible
Select at-risk patients with moderate vulnerability to delirium, which may maximize effectiveness
Target patients with at least moderate delirium severity and duration, as most likely to experience adverse outcomes
Delirium severity should be the primary outcome; measure short- and long-term clinical outcomes to maximize clinical relevance
Plan for handling informative censoring and missing data
Original publication
Advancing Delirium Treatment Trials in Older Adults: Recommendations for Future Trials From the Network for Investigation of Delirium: Unifying Scientists (NIDUS). Crit Care Med. Published 22 November 2024. doi:10.
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