Adverse childhood experiences and post-cesarean pain and in-hospital opioid use: a prospective cohort study
Main finding · Any opioid useResult — go to the resultAdjusted relative risk 1.52 CI 1.20–1.91Authors' conclusion
Adverse childoohd experiences were common and associated with higher opioid consumption and greater pain after cesarean delivery
Study context
- Population
- English or Spanish speaking women undergoing scheduled or intrapartum cesarean delivery under neuraxial anesthesia (2023–2024)
- Participants
- 129 participants
- Exposure
- ≥ 1 adverse childhood experiences (ACEs) vs no ACEs
- ACEsn = 53
- Outcome
- Opioid use post-delivery in milligram morphine equivalents (MME)
- Follow-up
- 0-48 h
Main finding
Any opioid use · first 48 h postpartum
Adjusted relative risk
1.52
CI 1.20–1.91
By group
ACEs vs No ACEs
aRR 1.52 (CI 1.20–1.91)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | aOR (CI) | |
|---|---|---|
| Opioid dose quartile vs lowest quartile2nd quartile · multinomial regression | 8.60 (2.47–29.9) | |
| Opioid dose quartile vs lowest quartile3rd quartile · multinomial regression | 5.74 (1.54–21.4) | |
| Opioid dose quartile vs lowest quartile4th (highest) quartile · multinomial regression | 4.54 (1.30–15.9) | |
| 0.050.21520Adjusted odds ratio (log scale) |
| Outcome | ACEs | No ACEs | P value |
|---|---|---|---|
| Average NRS pain score | 3/10 | 2/10 | P = 0.037 |
| SF-BPI worst pain score · 24-48 h postpartum | 7/10 | 6/10 | P = 0.029 |
Original publication
Adverse childhood experiences and post-cesarean pain and in-hospital opioid use: a prospective cohort study. Int J Obstet Anesth. Published 24 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →