Pediatric anesthesia & critical care
Alterations in the lipid profile of critically ill children in relation to outcome
Authors' conclusion
Critically ill children presented with low circulating levels of lipids. Low plasma cholesterol concentrations were associated with poor outcomes, most robustly for HDL-cholesterol.
Study context
- Population
- Critically ill children in PICU (PEPaNIC RCT)1,165 with admission samples
- Participants
- 1,440 children
- Comparison
- Early-PN vs Late-PN
Methodological detailsmatched subset, multivariable Cox and logistic regression
- Matched subset
- Multivariable Cox and logistic regression
Primary result
As reported in the abstract
Lipid profile and outcome
- Only HDL-cholesterol further decreased over time
- P < 0.0001
- Admission values lower in infants than older children and in patients with infection
- P < 0.05
- Lower admission HDL- and total-cholesterol independently associated with lower likelihood of earlier live PICU discharge
- P < 0.001
- Lower admission HDL- and total-cholesterol independently associated with higher risk of 90-day mortality
- P ≤ 0.01
- Higher triglycerides independently associated with higher risk of 90-day mortality
- P = 0.004
- Low admission HDL-cholesterol independently associated with higher risk of new infection
- P = 0.05
Original publication
Alterations in the lipid profile of critically ill children in relation to outcome. Crit Care. Published 4 March 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →