Altered Gut Microbiome Composition and Function in Individuals with Complex Regional Pain Syndrome
Authors' conclusion
These findings highlight unique compositional and functional changes in the gut microbiome of individuals with CRPS, thus contributing to the growing body of evidence supporting the role of the gut microbiome in chronic pain syndromes.
Study context
- Population
- Individuals with complex regional pain syndrome and matched pain-free controls from two geographically independent regions
- Participants
- 53 vs 52
- Comparison
- Complex regional pain syndrome (CRPS) patients vs pain-free controls
- CRPSn = 53
- Controlsn = 52reference
- Outcome
- Gut microbiome composition (differential abundance)
Methodological detailsage-, sex-, and ethnicity-matched, two geographically independent regions, 16S rRNA gene amplification, targeted metabolomic analysis, machine learning with validation cohort
- Age-, sex-, and ethnicity-matched
- Two geographically independent regions
- 16S rRNA gene amplification
- Targeted metabolomic analysis
- Machine learning with validation cohort
Main finding
As reported in the abstract
- Significant differences in several bacterial taxa in CRPS vs controls, incl. alterations in short-chain fatty acid-metabolizing species
Observational data: associations, not effects.
Further findings
Fecal and plasma short-chain fatty acid levels (targeted metabolomics)
- Differences in fecal and plasma short-chain fatty acid levels between CRPS and controls
Machine learning classification by microbiome composition
- Accurate classification of patients and controls in a geographically independent test cohort
Original publication
Altered Gut Microbiome Composition and Function in Individuals with Complex Regional Pain Syndrome. Anesthesiology. Published 5 March 2025. doi:10.
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