ICU sedation, delirium & recovery
Altered muscle transcriptome as molecular basis of long-term muscle weakness in survivors from critical illness
Authors' conclusion
Abnormal RNA-expression profiles 5 years after critical illness suggest disrupted mitochondrial function, disturbed lipid metabolism, and fibrosis, associated with lower long-term muscle strength and partly attributable to possibly avoidable risk factors.
Study context
- Population
- Survivors of critical illness requiring intensive care unit (ICU) admission, EPaNIC trial, 5 years after critical illness
- Participants
- 115 vs 30
- Comparison
- Former ICU patients 5 years after critical illness vs matched controls
- Former ICU-patientsn = 115
- Controlsn = 30reference
Methodological detailspre-planned, matched controls, RNA-sequencing
- Pre-planned
- Matched controls
- RNA-sequencing
Primary result
As reported in the abstract
Muscle transcriptome (differentially expressed RNAs) · 5 years
Down-regulated RNAs in former patients (adjusted for age, sex, BMI)
234
Up-regulated RNAs in former patients (adjusted for age, sex, BMI)
116
Further findings
Risk factors for abnormal RNA-expression
- Several treatments in-ICU and at 5-year follow-up associated with abnormal RNA-expression, most notably in-ICU early parenteral nutrition and glucocorticoid use
Original publication
Altered muscle transcriptome as molecular basis of long-term muscle weakness in survivors from critical illness. Intensive Care Med. Published 10 June 2025. doi:10.
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