Pediatric anesthesia & critical care
The Analgesic Effects of the Addition of Intravenous Ibuprofen to a Multimodal Analgesia Regimen for Pain Management After Pediatric Cardiac Surgery: A Randomized Controlled Study
Authors' conclusion
The addition of intravenous ibuprofen to a multimodal analgesia regimen for pain management after pediatric cardiac surgery improved postoperative analgesia in terms of reduction of opioid consumption and pain scores.
Study context
- Population
- Pediatric patients undergoing open cardiac surgery via midline sternotomy78 screened
- Participants
- 68 patients
- Comparison
- IV ibuprofen added to multimodal analgesia vs placebo
- Ibuprofenn = 34
- Controln = 34reference
- Primary endpoint
- Postoperative fentanyl consumption
- Follow-up
- 24 hours
Methodological detailsdouble-blinded, superiority, single-centre university hospital
- Double-blinded
- Superiority
- Single-centre university hospital
Primary result
As reported in the abstract
Total fentanyl consumption, first 24 h after extubation
P < 0.001
Secondary outcomes
| Outcome | P value |
|---|---|
| Postoperative modified objective pain score · 0, 2, 12, 16, 20 and 24 hoursMedian score significantly lower with ibuprofen | P < 0.05 |
Safety
Bleeding, epigastric pain, vomiting
- No significant increase with ibuprofen
Postoperative renal dysfunction
- Not reported in any patient
- 0
Original publication
The Analgesic Effects of the Addition of Intravenous Ibuprofen to a Multimodal Analgesia Regimen for Pain Management After Pediatric Cardiac Surgery: A Randomized Controlled Study. J Cardiothorac Vasc Anesth. Published 22 November 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →