The analgesic efficacy of intrathecal morphine compared to peripheral regional analgesia in total hip arthroplasty: A systematic review and meta-analysis
Authors' conclusion
We found no difference between intrathecal morphine and peripheral regional analgesia in regard to pain score at rest at 24 h.
Study context
- Population
- Patients scheduled for elective total hip arthroplasty under general or spinal anaesthesia
- Participants
- 471 patients · 8 RCTs
- Comparison
- Intrathecal morphine vs peripheral regional analgesia
- Outcome
- Coprimary: pain score at rest; cumulative IV morphine equivalent consumption
- Follow-up
- 24 h
Pooled result
As reported in the abstract
Coprimary outcomes: pain score at rest at 24 h; cumulative IV morphine equivalent consumption at 24 h
- Pain score at rest at 24 h: no difference between intrathecal morphine and peripheral regional analgesia (moderate quality of evidence)
- Coprimary outcomes
Further pooled results
| Outcome | Estimate | P value |
|---|---|---|
| Pain score at rest · 8-12 hI2 = 68%; intrathecal morphine superior | 1.24 (CI 0.60–1.88) | P = 0.0001 |
| Pain score on movement · 8-12 hI2 = 65%; intrathecal morphine superior | 1.15 (CI 0.12–2.17) | P = 0.03 |
Functional status
- No differences shown
Safety
| Outcome | Estimate | P value |
|---|---|---|
| In-hospital pruritusI2 = 0%; rate reduced with peripheral regional analgesia | 0.31 (CI 0.17–0.58) | P = 0.0002 |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
The analgesic efficacy of intrathecal morphine compared to peripheral regional analgesia in total hip arthroplasty: A systematic review and meta-analysis. Eur J Anaesthesiol. Published 17 June 2026. doi:10.
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