Analgesic efficacy of systemic lidocaine using lean body mass based dosing regime versus placebo in bariatric surgery: a prospective, randomised, double-blind, placebo-controlled, single-centre study
Authors' conclusion
Lidocaine does not improve postoperative pain scores, analgesia, or any secondary outcomes in patients undergoing bariatric surgery.
Study context
- Population
- Patients undergoing bariatric surgery137 completed
- Participants
- 140 patients
- Comparison
- IV lidocaine 1.5 mg kg-1 vs placebo during GA
- Primary endpoint
- Experienced pain (numeric rating scale (NRS) >3)
- Follow-up
- First 4 h postoperatively
Methodological detailsprospective, double-blind, placebo-controlled, single-centre
- Prospective
- Double-blind
- Placebo-controlled
- Single-centre
Primary result
As reported in the abstract
Any NRS >3 within first 4 h · first 4 h
P = 0.507
Secondary outcomes
Maximal pain score, opioid consumption, bowel function recovery, postoperative nausea and vomiting (PONV), hospital LOS
- No difference between groups
Original publication
Analgesic efficacy of systemic lidocaine using lean body mass based dosing regime versus placebo in bariatric surgery: a prospective, randomised, double-blind, placebo-controlled, single-centre study. Br J Anaesth. Published 12 May 2023. doi:10.
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