Pediatric anesthesia & critical care
Analysis of SEF95 derived from two processed EEG devices during pediatric anesthesia for non-cardiac surgery
Main finding · Agreement of paired BIS/SedLine SEF95Result — go to the resultBias (Bland-Altman) 0.62 Hz 95% limits of agreement CI - 4.08 to 5.32Authors' conclusion
SEF95 monitored by BIS or SedLine pediatric patients showed some differences, with deltas up to ± 4 Hz. Values appeared to be closer during the anesthesia maintenance phase.
Study context
- Population
- Children aged 12 months to 18 years undergoing non-cardiac surgery under anesthesia, tertiary pediatric hospital402 paired values
- Participants
- 51 children
- Exposure
- SEF95 from BIS vs SedLine, recorded simultaneously
- Outcome
- Agreement of SEF95 values between BIS and SedLine
Methodological detailssingle-centre, method comparison (Bland-Altman), Excluded if inadequate sensor fit or artifacts, Anesthesia administered according to anesthesiologists' preferences
- Single-centre
- Method comparison (Bland-Altman)
- Excluded if inadequate sensor fit or artifacts
- Anesthesia administered according to anesthesiologists' preferences
Main finding
Agreement of paired BIS/SedLine SEF95
Bias (Bland-Altman)
0.62 Hz
95% limits of agreement CI - 4.08 to 5.32
As reported in the abstract
- R² at linear regression (p < 0.0001)
- 0.73
- Delta SEF95 within ± 2 Hz
- 267 (66%)
- Delta SEF95 within ± 3 Hz (further)
- 67 (17%)
- Delta SEF95 within ± 4 Hz (further)
- 48 (12%)
- Delta SEF95 beyond ± 4 Hz
- 20
- SedLine SEF95 higher than BIS
- 40
- BIS SEF95 higher than SedLine
- 96
Observational data: associations, not effects.
Further findings
Median SEF95 deltas across time points
- Significant differences between values at 15 min and 60 min after skin incision vs extubation (p = 0.0017)
Original publication
Analysis of SEF95 derived from two processed EEG devices during pediatric anesthesia for non-cardiac surgery. J Clin Monit Comput. Published 13 August 2025. doi:10.
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