Antepartum mental health disorders and hypertensive disorders of pregnancy: a retrospective cohort study using the premier healthcare administrative database (2016–2020)
Authors' conclusion
Antepartum mood and anxiety disorders were associated with increased odds of hypertensive disorders, with anxiety conferring the highest odds.
Study context
- Population
- Obstetric patients ≥18 years who delivered from 1/10/15 to 12/31/20, US Premier Healthcare Administrative Database
- Participants
- 861,177 patients
- Exposure
- Antepartum mental health disorders vs none
- Outcome
- Hypertensive disorders (gestational hypertension, preeclampsia with and without severe features) diagnosed during birth hospitalization
Methodological detailsnationwide administrative database, multivariable logistic regression
- Nationwide administrative database
- Multivariable logistic regression
Main finding
As reported in the abstract
Hypertensive disorders
Each group vs no antepartum mental health disordersAdjusted odds ratio (95% CI)
Depressive disordersE-value 1.21
1.06(1.03–1.09)
AnxietyE-value 1.67
1.22(1.19–1.25)
Depressive and anxiety disordersE-value 1.59
1.19(1.16–1.23)
Bipolar disordersE-value 1.24
1.09(1.04–1.15)
Observational data: associations, not effects.
Original publication
Antepartum mental health disorders and hypertensive disorders of pregnancy: a retrospective cohort study using the premier healthcare administrative database (2016–2020). Int J Obstet Anesth. Published 5 May 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →