Appropriate Duration of Perioperative Intravenous Administration of Lidocaine to Provide Satisfactory Analgesia for Adult Patients Undergoing Colorectal Surgery: A Meta-Analysis of Randomized Controlled Trials
Authors' conclusion
The analgesic effect of intravenous lidocaine may depend on the duration of infusion
Study context
- Population
- Adults undergoing colorectal surgery
- Participants
- 548 adults · 11 studies
- Comparison
- Prolonged or short IV lidocaine infusion vs placebo
- Outcome
- Pain scores (VAS, 0-10 cm) at rest and on movement
- Follow-up
- 24 hours postoperatively
Methodological detailsrandom effects model, subgroups by infusion duration
- Random effects model
- Subgroups by infusion duration
Pooled result
As reported in the abstract
24 hours
Prolonged lidocaine infusion vs PlaceboMD, cm (95% CI)P value
At rest
−0.91(−1.54 to −0.28)
P = 0.02On movement
−1.69(−2.15 to −1.22)
P < 0.001Further pooled results
| Outcome | MD (days) (95% CI) | P value | |
|---|---|---|---|
| Hospital LOSProlonged lidocaine infusion vs Placebo | −1.30 (−1.72 to −0.88) | P < 0.001 | |
| −2−101Difference, days (linear scale) |
| Outcome | MD (hours) (95% CI) | P value | |
|---|---|---|---|
| Time to first postoperative defecationProlonged lidocaine infusion vs Placebo | −12.51 (−22.67 to −2.34) | P = 0.02 | |
| −30−20−10010Difference, hours (linear scale) |
Pain scores at 12 h (rest) and 12 and 48 h (movement)
- Reduced with prolonged infusion vs placebo; not with short infusion
- No significant difference between prolonged and short infusion
Other outcomes (analgesic consumption, complications)
- No differences between groups
Original publication
Appropriate Duration of Perioperative Intravenous Administration of Lidocaine to Provide Satisfactory Analgesia for Adult Patients Undergoing Colorectal Surgery: A Meta-Analysis of Randomized Controlled Trials. Anesth Analg. Published 20 January 2023. doi:10.
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