Airway management

Arterial partial pressure of oxygen as a marker of airway closure does not correlate with the efficacy of pre-oxygenation: A prospective cohort study

Eur J AnaesthesiolPublished Prospective observational study

Authors' conclusion

After 3 min of pre-oxygenation, F E' O 2 , even in the elderly, indicated a high enough alveolar oxygen concentration to promote atelectasis after induction, therefore, it is still unclear why atelectasis formation diminishes after middle age.

Study context

Population
Adults aged 40 to 79 years presenting for elective noncardiac surgery, two regional hospitals in Sweden, 2018–2021
Participants
120 adults
Outcome
Correlation between efficacy of pre-oxygenation (F E' O 2 after 3 min of pre-oxygenation) and PaO2 on room air
Follow-up
3 min
Methodological detailsmulticentre
  • Multicentre

Main finding

As reported in the abstract

Correlation of F E' O 2 at 3 min with PaO2

No linear correlation between F E' O 2 at 3 min and PaO2 (Pearson's r)

−0.038

P = 0.684

Observational data: associations, not effects.

Further findings

Correlation of F E' O 2 at 3 min with age

No linear correlation between F E' O 2 at 3 min and age (Pearson's r)
−0.113, P = 0.223

F E' O 2 at 3 min, whole population

Mean ± SD F E' O 2 at 3 min
0.87 ± 0.05

Original publication

Arterial partial pressure of oxygen as a marker of airway closure does not correlate with the efficacy of pre-oxygenation: A prospective cohort study. Eur J Anaesthesiol. Published 30 June 2023. doi:10.1097/eja.0000000000001869

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