Perioperative medicine & outcomes
Assessing the use of Extended Venous Thromboembolism Prophylaxis on the Rates of Venous Thromboembolism and Postpancreatectomy Hemorrhage Following Pancreatectomy for Malignancy
Authors' conclusion
Extended VTE prophylaxis following pancreatectomy for malignancy was not associated with differences in postdischarge VTE and PPH rates.
Study context
- Population
- Patients who underwent pancreatectomy for pancreatic or periampullary malignancy, single institution, 2004–2021
- Participants
- 478 patients
- Exposure
- Extended venous thromboembolism (VTE) prophylaxis with enoxaparin vs no extended prophylaxis
- Outcome
- VTE and PPH rates (postdischarge)
- Follow-up
- Within 90 days of discharge
Methodological detailssingle-institution, pre-post implementation
- Single-institution
- Pre-post implementation
Main finding
As reported in the abstract
Postdischarge VTE and PPH
Postdischarge VTE rate
2.3% vs 2.8%
P = 0.99
Extended VTE prophylaxis
Postdischarge PPH rate
3.4% vs 1.9%
P = 0.43
Extended VTE prophylaxis
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | P value |
|---|---|---|
| VTE and PPH in patients on antiplatelet agents (subgroup)Extended VTE prophylaxis vs No extended prophylaxis | VTE rate 3.9 vs. 0% | P = 0.31 |
| VTE and PPH in patients on antiplatelet agents (subgroup)Extended VTE prophylaxis vs No extended prophylaxis | PPH rate 3.0 vs. 4.5% | P = 0.64 |
Overall postoperative VTE and PPH (all patients)
- Postoperative VTE
- 22 (4.6%)
- Postdischarge VTE
- 12 (2.5%)
- PPH
- 25 (5.2%)
- Postdischarge PPH
- 13 (2.7%)
Original publication
Assessing the use of Extended Venous Thromboembolism Prophylaxis on the Rates of Venous Thromboembolism and Postpancreatectomy Hemorrhage Following Pancreatectomy for Malignancy. Ann Surg. Published 7 July 2022. doi:10.
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