Association Between Cannabis Use and Opioid Consumption, Pain, and Respiratory Complications After Surgery: A Retrospective Cohort Analysis
Main findingResult — go to the resultAdjusted ratio of geometric means 1.30 95% CI 1.22–1.38Authors' conclusion
Adult cannabis users undergoing surgeries were found to have significantly higher postoperative opioid consumption and pain scores than nonusers. Cannabis use did not have a clinically meaningful association with hypoxia or composite pulmonary complications.
Study context
- Population
- Adults having elective surgery at Cleveland Clinic Main Campus, January 2010–December 2020; regional anaesthesia or chronic pain diagnosis excluded
- Participants
- 34,521 adults
- Exposure
- Cannabis use within 30 days before surgery vs never use
- Cannabis usersn = 1,683
- Outcome
- Postoperative opioid consumption
- Follow-up
- First 24 postoperative hours
Methodological detailspropensity score-based IPTW, single-centre
- Propensity score-based IPTW
- Single-centre
Main finding
As reported in the abstract
Adjusted ratio of geometric means
1.30
95% CI 1.22–1.38
P < 0.0001
Cannabis users vs Nonusers
adjusted ratio of geometric means 1.30 (95% CI 1.22–1.38); P < 0.0001
Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Association Between Cannabis Use and Opioid Consumption, Pain, and Respiratory Complications After Surgery: A Retrospective Cohort Analysis. Anesth Analg. Published 8 January 2024. doi:10.
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