Cardiac arrest & resuscitation
Association between the extent of diffusion restriction on brain diffusion-weighted imaging and neurological outcomes after an out-of-hospital cardiac arrest
Authors' conclusion
More extensive diffusion restriction on DWI-ASPECTS in patients with OHCA who underwent TTM was associated with 6-month unfavourable neurological outcomes.
Study context
- Population
- Patients with out-of-hospital cardiac arrest (OHCA) treated with targeted temperature management (TTM) who underwent brain MRI within 10 days, 2012–2021
- Participants
- 301 patients
- Comparison
- Unfavourable outcome vs Favourable outcome
- Favourable outcomen = 108reference
- Outcome
- Unfavourable neurological outcome
- Follow-up
- 6 months
Methodological detailsfive-fold cross-validation
- Five-fold cross-validation
Performance
As reported in the abstract
Whole-brain DWI-ASPECTS by 6-month neurological outcome
Unfavourable outcome
31
median · IQR 26–33
Favourable outcome
0
median · IQR 0–1
P < 0.001
- Area under the ROC curve (AUROC) of whole-brain DWI-ASPECTS
- 0.957 (95% CI 0.928-0.977)
- Cut-off ≥8: specificity for unfavourable outcome
- 100% (95% CI 96.6-100)
- Cut-off ≥8: sensitivity for unfavourable outcome
- 89.6% (95% CI 84.4-93.6)
- Mean AUROC (five-fold cross-validation)
- 0.956
Further findings
Internal validation (five-fold cross-validation)
- Mean AUROC
- 0.956
Original publication
Association between the extent of diffusion restriction on brain diffusion-weighted imaging and neurological outcomes after an out-of-hospital cardiac arrest. Resuscitation. Published 9 March 2023. doi:10.
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