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The Association Between Malnutrition and High Protein Treatment on Outcomes in Critically Ill Patients: A Post Hoc Analysis of the EFFORT Protein Randomized Trial
Primary result · TTDA by preexisting malnutritionResult — go to the resultAdjusted hazard ratio 0.81 95% CI 0.67–0.98Authors' conclusion
Malnutrition was associated with slower TTDA, but high protein treatment did not modify the association.
Study context
- Population
- Critically ill patients
- Participants
- 1,301 patients
- Comparison
- Malnutrition vs No malnutrition
- Primary endpoint
- Time to discharge alive (TTDA)
Methodological details16 countries, multivariable regression
- 16 countries
- Multivariable regression
Primary result
TTDA by preexisting malnutrition
Adjusted hazard ratio
0.81
95% CI 0.67–0.98
Malnutrition vs No malnutrition
aHR 0.81 (95% CI 0.67–0.98)
As reported in the abstract
- Prevalence of preexisting malnutrition
- 43.8%
Further findings
| Outcome | aHR (95% CI) | |
|---|---|---|
| TTDA with high protein treatment, by preexisting malnutrition (subgroup)With preexisting malnutrition · not associated with TTDA | 0.84 (0.63–1.11) | |
| TTDA with high protein treatment, by preexisting malnutrition (subgroup)Without preexisting malnutrition · not associated with TTDA | 0.97 (0.77–1.21) | |
| 0.512Adjusted hazard ratio (log scale) |
Effect modification of malnutrition–time to discharge alive (TTDA) association by protein delivery
| Ratio of aHR (95% CI) | ||
|---|---|---|
| Effect modificationNo effect modification observed | 0.84 (0.58–1.20) | |
| 0.512Ratio of aHR (log scale) |
Average, g/kg per day
| Outcome | High protein | Usual protein |
|---|---|---|
| Average protein delivery | 1.6 | 0.9 |
Prevalence of preexisting malnutrition
- Prevalence of preexisting malnutrition
- 43.8%
Cumulative incidence of live hospital discharge, with vs without preexisting malnutrition · day 60
- With preexisting malnutrition
- 41.2%
- Without preexisting malnutrition
- 52.9%
Original publication
The Association Between Malnutrition and High Protein Treatment on Outcomes in Critically Ill Patients: A Post Hoc Analysis of the EFFORT Protein Randomized Trial. Chest. Published 12 February 2024. doi:10.
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