Neuroanesthesia & neurocritical care
Association between perioperative flurbiprofen administration and acute kidney injury (AKI) in spine surgery: a retrospective cohort study
Main finding · Postoperative AKIResult — go to the resultOdds ratio 0.51 95% CI 0.31–0.82Authors' conclusion
The study concluded that perioperative flurbiprofen treatment was associated with a lower risk of postoperative AKI in adult patients undergoing spinal surgery.
Study context
- Population
- Adults undergoing spinal surgery, Third Xiangya Hospital of Central South University, January 1, 2012–July 31, 2018
- Participants
- 3,882 adults
- Exposure
- Intraoperative flurbiprofen vs no flurbiprofen
- Outcome
- Incidence of postoperative AKI
Methodological detailssingle-centre, multivariable regression adjustment
- Single-centre
- Multivariable regression adjustment
Main finding
Postoperative AKI
Odds ratio
0.51
95% CI 0.31–0.82
By group
Flurbiprofen vs Non-flurbiprofen
OR 0.51 (95% CI 0.31–0.82)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| Postoperative AKI, patients without diabetes (subgroup) | 0.61 (0.19–0.74) | |
| Postoperative AKI, surgical time 2-5 h (subgroup) | 0.54 (0.23–0.75) | |
| Postoperative AKI, preoperative anemia (subgroup) | 0.57 (0.21–0.74) | |
| 0.20.5125Odds ratio (log scale) |
Original publication
Association between perioperative flurbiprofen administration and acute kidney injury (AKI) in spine surgery: a retrospective cohort study. Perioper Med (Lond). Published 18 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →