Perioperative medicine & outcomes
The association between postoperative myocardial injury of unexplained aetiology after noncardiac surgery and sex and cancer on 1-yr survival: a retrospective, single-centre, observational cohort study
Main finding · PMI aetiology distribution and 1-yr mortalityResult — go to the resultRelative risk 1.5 95% CI 1.1–2.1Authors' conclusion
In approximately half of the patients with a diagnosis of PMI, PMI aetiology was either related to perioperative haemodynamic/respiratory events or the aetiology was unexplained. These patients had an increased associated mortality risk. Women more often had PMI of likely haemodynamic/respiratory causes. Mortality risk in those with PMI was similar between sexes and between those undergoing cancer surgery vs non-cancer surgery.
Study context
- Population
- Patients aged ≥60 yr undergoing noncardiac surgery823 (21%) with postoperative myocardial injury (PMI)
- Participants
- 3,885 patients
- Exposure
- PMI aetiology groups; interaction with sex and cancer surgery
- Myocardial infarction (MI)n = 32
- Extra-cardiac diseasen = 201
- Known cardiac diseasen = 174
- Haemodynamic/respiratory eventsn = 269
- Unexplained aetiologyn = 147
- Outcome
- Proportion of patients developing PMI of unknown aetiology and its association with 1-yr mortality
- Follow-up
- 1 yr
Methodological detailssingle-centre, observational
- Single-centre
- Observational
Main finding
PMI aetiology distribution and 1-yr mortality
Relative risk
1.5
95% CI 1.1–2.1
Events by group
As reported in the abstract
Observational data: associations, not effects.
Further findings
PMI aetiology by sex
- PMI caused by MI or known cardiac disease more often in men; women more often had PMI owing to perioperative haemodynamic/respiratory factors
Interaction of PMI with sex or cancer surgery on mortality
- No interaction found between PMI and sex or cancer surgery on mortality risk
Original publication
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