Association between postpartum depression and chronic postsurgical pain after Cesarean delivery: a secondary analysis of a randomized trial
An erratum to this article was published (Can J Anaesth, Feb 2026 ↗)
Primary result · CPSPResult — go to the resultOdds ratio 4.05 95% CI 1.42–11.5Authors' conclusion
In this secondary analysis of a previous randomized trial, we found a significant association between PPD and CPSP following CD.
Study context
- Population
- Patients undergoing Cesarean delivery (CD) in Nepal under spinal anesthesia, randomised to intrathecal morphine or normal saline276 analysed
- Participants
- 290 patients
- Comparison
- PPD vs no PPD
- PPDn = 20
- Primary endpoint
- Occurrence of CPSP
- Follow-up
- 3 and 6 months
Methodological detailsmultivariable model, causal mediation analysis
- Multivariable model
- Causal mediation analysis
Primary result
CPSP · 3 months
Odds ratio
4.05
95% CI 1.42–11.5
P = 0.009
PPD vs No PPD
OR 4.05 (95% CI 1.42–11.5); P = 0.009
As reported in the abstract
Further findings
Mediating effect of PPD between acute severe postoperative pain and chronic postsurgical pain (CPSP)
- No mediating effect of PPD (causal mediation analysis)
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Association between postpartum depression and chronic postsurgical pain after Cesarean delivery: a secondary analysis of a randomized trial. Can J Anaesth. Published 22 July 2025. doi:10.
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