Cardiac arrest & resuscitation
Association between pupillary examinations and prognosis in patients with out-of-hospital cardiac arrest who underwent extracorporeal cardiopulmonary resuscitation: a retrospective multicentre cohort study
Authors' conclusion
Among the patients with OHCA who underwent ECPR and showed poor pupillary examination findings upon hospital arrival, 10.2% had favourable neurological outcome at hospital discharge. A positive PLR after the establishment of ECPR was significantly associated with favourable neurological outcome.
Study context
- Population
- Adults with out-of-hospital cardiac arrest (OHCA) who underwent extracorporeal cardiopulmonary resuscitation (ECPR) with negative pupillary light reflex (PLR) and mydriasis on hospital arrival, 36 institutions in Japan, 2013–2018 (SAVE-J II)of 2,157 enrolled
- Participants
- 723 adults
- Exposure
- Pupillary findings at ICU admission after ECPR establishment
- Outcome
- Favourable neurological outcome (Cerebral Performance Category 1 or 2)
- Follow-up
- Hospital discharge
Methodological detailsmulticentre registry, multivariable logistic regression
- Multicentre registry
- Multivariable logistic regression
Main finding
As reported in the abstract
Favourable neurological outcome
Odds ratio (95% CI)
Positive PLR at ICU admissionmultivariable; significant
11.3(5.17–24.7)
Normal pupil diameter at ICU admissionmultivariable; not significant
1.10(0.52–2.32)
- Favourable neurological outcome, all analysed
- 74 (10.2%)
Observational data: associations, not effects.
Original publication
Association between pupillary examinations and prognosis in patients with out-of-hospital cardiac arrest who underwent extracorporeal cardiopulmonary resuscitation: a retrospective multicentre cohort study. Ann Intensive Care. Published 6 March 2024. doi:10.
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