ICU sedation, delirium & recovery
Association Between the Ultrasound Evaluation of Muscle Mass and Adverse Outcomes in Critically Ill Patients: A Prospective Cohort Study
Authors' conclusion
Low baseline RF-CSA was associated with increased ICU mortality. Admission RF-CSA was lower in women, with high nutritional risk, in older subjects and with lower body size. Absolute muscle mass was significantly associated with mortality, with no significant increase in this relationship when adjusting for sex or body size.
Study context
- Population
- Consecutive mechanically ventilated intensive care unit (ICU) patients with predicted LOS >72 hours, university-affiliated hospital183 ICU survivors
- Participants
- 316 participants
- Exposure
- Baseline ultrasound rectus femoris cross-sectional area (RF-CSA) and ICU mortality
- Outcome
- ICU mortality (association with baseline RF-CSA)
Methodological detailssingle-centre, observational, 3 ICUs (general, neuroscience, COVID-19), multivariable logistic regression
- Single-centre
- Observational
- 3 ICUs (general, neuroscience, COVID-19)
- Multivariable logistic regression
Main finding
As reported in the abstract
ICU mortality, multivariable association
Odds ratio (95% CI)
Lower RF-CSAlower RF-CSA associated with ICU mortality
0.41(0.29–0.58)
Older age
1.03(1.01–1.05)
Neuroscience ICU
0.82(0.38–1.79)
COVID-19 ICU
4.1(2.01–8.38)
Higher modified NUTRIC score
1.43(1.21–1.70)
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Values | P value |
|---|---|---|
| Diagnostic performance of RF-CSA for ICU mortalityUnadjusted RF-CSA vs CSA-sex, CSA-BSA, CSA-H2 · not significantly different | Unadjusted RF-CSA AUC 0.720 [0.663-0.776] | P = 0.1487 |
Determinants of baseline RF-CSA
- Baseline RF-CSA lower in women, with higher nutritional risk, older age, and larger body size
Original publication
Association Between the Ultrasound Evaluation of Muscle Mass and Adverse Outcomes in Critically Ill Patients: A Prospective Cohort Study. Anesth Analg. Published 10 January 2025. doi:10.
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