Association between tranexamic acid administration and mortality based on the trauma phenotype: a retrospective analysis of a nationwide trauma registry in Japan
Authors' conclusion
We found an association between trauma phenotypes and in-hospital mortality, indicating that treatment with TXA could potentially influence this relationship.
Study context
- Population
- Patients with blunt trauma in the Japan Trauma Data Bank, 2019 to 2021, categorised into eight trauma phenotypes8 trauma phenotypes
- Participants
- 53,703 patients
- Exposure
- Tranexamic acid (TXA) vs no TXA, by trauma phenotype
- TXAn = 8,046
- Outcome
- In-hospital mortality
Methodological detailsnationwide trauma registry, inverse probability treatment weighting
- Nationwide trauma registry
- Inverse probability treatment weighting
Main finding
As reported in the abstract
In-hospital mortality with TXA administration, by trauma phenotype (subgroup)
Odds ratio (95% CI)
Trauma phenotype 1
0.68(0.57–0.81)
Trauma phenotype 2
0.73(0.66–0.81)
Trauma phenotype 6
0.52(0.39–0.70)
Trauma phenotype 8
0.67(0.60–0.75)
Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Association between tranexamic acid administration and mortality based on the trauma phenotype: a retrospective analysis of a nationwide trauma registry in Japan. Crit Care. Published 19 March 2024. doi:10.
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