Pediatric anesthesia & critical care
Association of dexmedetomidine use with haemodynamics, postoperative recovery, and cost in paediatric anaesthesia: a hospital registry study
Main finding · PACU LOSResult — go to the resultAdjusted absolute difference 19.7 min 95% CI 18.0–21.4Authors' conclusion
Intraoperative use of dexmedetomidine is associated with unwarranted haemodynamic effects, longer postanaesthesia care unit length of stay, and higher costs, without preventive effects on emergence delirium.
Study context
- Population
- Paediatric patients aged 0–12 yr, Bronx, NY, USA, 2016–2021, matched with Healthcare Cost and Utilization Project-Kids' Inpatient Database (HCUP-KID)
- Participants
- 18,104 patients
- Exposure
- Intraoperative dexmedetomidine vs no dexmedetomidine
- Outcome
- PACU LOS
Methodological detailshospital registry, single-centre
- Hospital registry
- Single-centre
Main finding
As reported in the abstract
Adjusted absolute difference
19.7 min
95% CI 18.0–21.4
P < 0.001
By group
Dexmedetomidine vs No dexmedetomidine
adjusted absolute difference 19.7 min (95% CI 18.0–21.4); P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | Adjusted absolute difference (min) (95% CI) | P value | |
|---|---|---|---|
| PACU LOS, children aged ≤2 yr with short (≤60 min) ambulatory procedures (subgroup) | 33.3 (26.3–40.7) | P < 0.001 | |
| −200204060Difference, min (linear scale) |
| Outcome | aOR (95% CI) | P value | |
|---|---|---|---|
| Emergence delirium requiring postanaesthesia i.v. sedativesNo preventive effect | 1.67 (1.04–2.68) | P = 0.034 | |
| 0.20.5125Adjusted odds ratio (log scale) |
| Outcome | Higher total hospital costs (USD) (95% CI) |
|---|---|
| Total hospital costs | 1311 (835–1800) |
- PACU LOS, children aged ≤2 yr with short (≤60 min) ambulatory procedures (subgroup): P-for-interaction <0.001
Intraoperative dexmedetomidine use, 2016 to 2021
- Use increased from 51.7% to 85.7% (P<0.001)
Safety
| Outcome | aOR (95% CI) | P value | |
|---|---|---|---|
| Intraoperative MAP below 55 mm Hg | 1.27 (1.16–1.39) | P < 0.001 | |
| Heart rate below 100 beats min-1 | 1.32 (1.21–1.45) | P < 0.001 | |
| 0.512Adjusted odds ratio (log scale) |
Original publication
Association of dexmedetomidine use with haemodynamics, postoperative recovery, and cost in paediatric anaesthesia: a hospital registry study. Br J Anaesth. Published 17 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →