Perioperative medicine & outcomes
Association of Intravenous Neostigmine and Anticholinergics or Sugammadex with Postoperative Delirium: A Retrospective Cohort Study
Main findingResult — go to the resultOdds ratio 1.33 95% CI 0.91–1.95Authors' conclusion
Compared to neostigmine, use of sugammadex for reversal of neuromuscular block was not associated with an increased risk of postoperative delirium in this retrospective single-center study.
Study context
- Population
- Adults having GA for noncardiac surgery who received neostigmine or sugammadex, January 2016 to March 2022
- Participants
- 49,468 cases
- Exposure
- Sugammadex vs Neostigmine
- Sugammadexn = 6,881
- Neostigminen = 42,587reference
- Outcome
- Delirium (≥1 positive brief Confusion Assessment Method [brief Confusion Assessment Method (bCAM)] screening)
- Follow-up
- First 4 days after surgery
Methodological detailssingle-centre, inverse propensity score weighting, propensity score calibration
- Single-centre
- Inverse propensity score weighting
- Propensity score calibration
Main finding
As reported in the abstract
Odds ratio
1.33
95% CI 0.91–1.95
P = 0.147
By group
Sugammadex vs Neostigmine
OR 1.33 (95% CI 0.91–1.95); P = 0.147
Observational data: associations, not effects.
Secondary outcomes
| Outcome | OR (CI) | P value | |
|---|---|---|---|
| Early delirium · within 24 hours of surgery | 1.71 (1.07–2.72) | P = 0.025 | |
| Delirium, cases with ≥6 bCAM measurements POD 1 to 4 (sensitivity analysis) | 1.20 (0.82–1.77) | P = 0.346 | |
| 0.20.5125Odds ratio (log scale) |
Treatment-by-age interaction
- No interaction for postoperative delirium
- P = 0.637
- No interaction for early delirium
- P = 0.904
Original publication
Association of Intravenous Neostigmine and Anticholinergics or Sugammadex with Postoperative Delirium: A Retrospective Cohort Study. Anesth Analg. Published 16 December 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →