Cardiac arrest & resuscitation
Association of non-cardiac depolarization-blocking drugs with first-registered heart rhythm and survival in out-of-hospital cardiac arrest
Main finding · Non-shockable rhythmResult — go to the resultOdds ratio 1.62 95 % CI 1.48–1.79Authors' conclusion
Use of non-cardiac DB-drugs was associated with increased odds of non-shockable rhythm in OHCA and with lower 30-day survival following OHCA.
Study context
- Population
- Patients with out-of-hospital cardiac arrest (OHCA) of medical causes, Danish Cardiac Arrest Registry, 2001–2020
- Participants
- 54,370 patients
- Exposure
- Non-cardiac depolarization-blocking (DB)-drug users vs non-users
- Non-cardiac DB-drug usersn = 6,284
- Outcome
- Non-shockable initial heart rhythm and 30-day survival
Methodological detailsnationwide registry
- Nationwide registry
Main finding
Non-shockable rhythm
Odds ratio
1.62
95 % CI 1.48–1.79
Non-cardiac DB-drug users vs Non-users
OR 1.62 (95 % CI 1.48–1.79)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | OR (95 % CI) | |
|---|---|---|
| 30-day survival | 0.81 (0.69–0.95) | |
| Non-shockable rhythm, by sex and age (subgroups)Non-cardiac DB-drug users vs Non-users · men | 1.72 (1.53–1.95) | |
| Non-shockable rhythm, by sex and age (subgroups)Non-cardiac DB-drug users vs Non-users · women | 1.46 (1.26–1.70) | |
| Non-shockable rhythm, by sex and age (subgroups)Non-cardiac DB-drug users vs Non-users · <60 years | 1.91 (1.54–2.39) | |
| Non-shockable rhythm, by sex and age (subgroups)Non-cardiac DB-drug users vs Non-users · >60 years | 1.57 (1.41–1.74) | |
| 0.512Odds ratio (log scale) |
Non-shockable rhythm, by sex and age (subgroups)
- Consistent in the absence of pre-existing psychiatric or non-CV disease, or when stratified by year of OHCA
Original publication
Association of non-cardiac depolarization-blocking drugs with first-registered heart rhythm and survival in out-of-hospital cardiac arrest. Resuscitation. Published 19 November 2025. doi:10.
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