Neuroanesthesia & neurocritical care
Association of postoperative hypernatremia with outcomes after elective craniotomy
Authors' conclusion
Hypernatremia is common after elective craniotomy, and its presence is associated with increased mortality and complications, particularly in cases of severe hypernatremia.
Study context
- Population
- Adults undergoing elective craniotomy, excluding pituitary tumours, intracerebral haemorrhage, SAH or TBI
- Participants
- 10,223 adults
- Exposure
- Mild, moderate or severe postoperative hypernatremia
- Outcome
- 30-day mortality by hypernatremia severity
- Follow-up
- 30 days
Methodological detailshigh-volume centre, adjusted logistic regression
- High-volume centre
- Adjusted logistic regression
Main finding
As reported in the abstract
Odds ratio (95% CI)
Mild hypernatremia
3.79(2.46–5.85)
Moderate hypernatremia
17.73(11.17–28.12)
Severe hypernatremia
67.00(40.44–111.00)
Observational data: associations, not effects.
Further findings
Incidence of postoperative hypernatremia
- Developed postoperative hypernatremia
- 14.9% (1519)
Overall postoperative mortality · 30 days
- Overall 30-day mortality rate
- 1.7% (175)
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Association of postoperative hypernatremia with outcomes after elective craniotomy. J Clin Anesth. Published 7 November 2023. doi:10.
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