Association of Whole Blood With Survival Among Patients Presenting With Severe Hemorrhage in US and Canadian Adult Civilian Trauma Centers
Errata to this article were published (JAMA Surg, 1 May 2023 ↗ · 1 May 2023 ↗)
Main finding · MortalityResult — go to the resultHazard ratio 0.63 95% CI 0.41–0.96Authors' conclusion
In this cohort study, receipt of WB-MTP was associated with improved survival in trauma patients presenting with severe hemorrhage, with a survival benefit found early after transfusion.
Study context
- Population
- Adult trauma patients with SBP <90 mm Hg, shock index >1 and ≥4 units RBC within 1 hour of emergency department (ED) arrival, level I/II US and Canadian adult civilian trauma centers (ACS TQIP 2017–2018); burns, death within 1 hour and interfacility transfers excluded
- Participants
- 2,785 patients
- Exposure
- WB-MTP vs MTP alone
- Outcome
- Survival
- Follow-up
- 24 hours and 30 days
Methodological detailsmulticentre registry
- Multicentre registry
Main finding
Mortality · 24 hours
Hazard ratio
0.63
95% CI 0.41–0.96
P = 0.03
WB-MTP vs MTP-only
HR 0.63 (95% CI 0.41–0.96); P = 0.03
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Mortality · 30 daysWB-MTP vs MTP-only · co-primary outcome | 0.53 (0.31–0.93) | P = 0.02 | |
| 0.20.5125Hazard ratio (log scale) |
Survival curve
- Separation within 5 hours of ED presentation
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Association of Whole Blood With Survival Among Patients Presenting With Severe Hemorrhage in US and Canadian Adult Civilian Trauma Centers. JAMA Surg. Published 1 May 2023. doi:10.
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