Association of opioid utilization in the intensive care unit and opioid prescriptions at hospital discharge in opioid-naïve non-surgical patients who received enhanced oxygen therapy
Authors' conclusion
Increased opioid utilization during intensive care unit stays was associated with higher odds of opioid prescriptions at discharge in opioid-naïve, non-surgical patients.
Study context
- Population
- Opioid-naïve, non-surgical adults with community-based ICU stays ≥48 h who received enhanced oxygen therapy
- Participants
- 260 participants
- Comparison
- Opioid utilization in ICU among cases vs controls
- Casesn = 33
- Outcome
- Opioid prescription at hospital discharge, by ICU opioid utilization (cumulative and average daily oral morphine equivalents)
- Follow-up
- Hospital discharge
Methodological detailsmultivariable regression
- Multivariable regression
Main finding
As reported in the abstract
Opioid prescription at discharge
Odds
6.63
P < 0.001
>90 cumulative morphine equivalents in ICU · 6.63 times higher odds
Odds increase
3 %
P = 0.011
Each additional 10 daily morphine equivalents
Cases
12.7 %
33
Observational data: associations, not effects.
Further findings
| Outcome | Cases | Controls | P value |
|---|---|---|---|
| Cumulative morphine equivalents during ICU stay | 3362.4 (SE 1102.5) | 1024.9 (SE 240.0) | P = 0.002 |
| Average daily morphine equivalents during ICU stay | 129.8 (SE 36.9) | 61.2 (SE 10.7) | P = 0.03 |
Original publication
Association of opioid utilization in the intensive care unit and opioid prescriptions at hospital discharge in opioid-naïve non-surgical patients who received enhanced oxygen therapy. J Crit Care. Published 7 March 2025. doi:10.
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