Pediatric anesthesia & critical care
Association of serum lactate with outcome after pediatric out-of-hospital cardiac arrest: a secondary analysis of the Therapeutic Hypothermia After Pediatric Cardiac Arrest (THAPCA) trial
Authors' conclusion
Among subjects enrolled in the THAPCA-OH trial, higher lactates within 6-h of ROSC were associated with unfavorable outcome at one year.
Study context
- Population
- Children after out-of-hospital cardiac arrest (OHCA) in the THAPCA-OH trial with at least one lactate measurement within 24 h of return of spontaneous circulation (ROSC)82% unfavorable outcome
- Participants
- 213 children
- Comparison
- Unfavorable vs favorable 12-month outcome by lactate within 6 h of ROSC
- Primary endpoint
- Unfavorable neurobehavioral functioning or death
- Follow-up
- 12 months
Primary result
As reported in the abstract
First lactate within 6 h of ROSC by 12-month outcome
Unfavorable outcome
7.8
median
Favorable outcome
3.1
median
Difference (95% CI)
Unfavorable outcome vs Favorable outcome
4.8(3.7–5.9)
- Per 1 mmol/L lactate increase · odds of primary unfavorable outcome
- odds 1.40 (95% CI 1.17–1.69)
Further findings
Median
| Outcome | Died in hospital | Survivors | Difference (95% CI) | |
|---|---|---|---|---|
| First lactate within 6 h of ROSC, hospital death vs survival | 8.6 | 3.6 | 5.1 (4.0–6.1) | |
| −50510Difference (linear scale) |
Original publication
Association of serum lactate with outcome after pediatric out-of-hospital cardiac arrest: a secondary analysis of the Therapeutic Hypothermia After Pediatric Cardiac Arrest (THAPCA) trial. Resuscitation. Published 18 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →