Perioperative medicine & outcomes
Association of sugammadex reversal of neuromuscular block and postoperative length of stay in the ambulatory care facility: a multicentre hospital registry study
Main finding · PLOS-ACFResult — go to the resultAdjusted difference −9.5 min 95% CI −10.5 to −8.5Authors' conclusion
Reversal with sugammadex compared with neostigmine was associated with a small decrease in postoperative length of stay in the ambulatory care unit.
Study context
- Population
- Patients undergoing ambulatory surgery with GA and NMB, 2016–2021, two large academic healthcare networks, US
- Participants
- 29,316 patients
- Exposure
- Sugammadex vs neostigmine reversal of NMB
- Sugammadexn = 8,945
- Neostigminen = 20,371reference
- Outcome
- Postoperative LOS in the ambulatory care facility (postoperative length of stay in the ambulatory care facility (PLOS-ACF))
Methodological detailsmulticentre hospital registry, adjusted analysis
- Multicentre hospital registry
- Adjusted analysis
Main finding
PLOS-ACF
Adjusted difference
−9.5 min
95% CI −10.5 to −8.5
P < 0.001
Sugammadex vs Neostigmine
adjusted difference −9.5 min (95% CI −10.5 to −8.5); P < 0.001
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Adjusted difference (min) (95% CI) | P value | |
|---|---|---|---|
| PLOS-ACF (subgroup: age >65 yr, ASA >2, procedures <2 h) | −18.2 (−23.8 to −12.4) | P < 0.001 | |
| −30−20−10010Difference, min (linear scale) |
PONV (post hoc)
P < 0.001
| Outcome | Adjusted difference (95% CI) | P value |
|---|---|---|
| Direct hospital costs (post hoc) | -US$77 (-$88 to -$66) | P < 0.001 |
| Direct hospital costs (subgroup: age >65 yr, ASA >2, procedures <2 h) | -$176 (-$220 to -$128) | P < 0.001 |
PONV (post hoc)
- Reduced PONV mediated the effect on LOS
Original publication
Association of sugammadex reversal of neuromuscular block and postoperative length of stay in the ambulatory care facility: a multicentre hospital registry study. Br J Anaesth. Published 17 December 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →