Associations of baseline characteristics, patient-reported outcomes, and satisfaction with pain therapy with the patient's global impression of change: a prospective cohort study
Authors' conclusion
Although all four domains contributed to PGIC after surgery, pain intensity was the most important.
Study context
- Population
- Adults after total knee arthroplasty, sternotomy, breast cancer surgery or endometriosis surgery (PROMPT NIT-1 study)
- Participants
- 2,661 adults · 18 sites
- Outcome
- Association of 10 patient's specific impressions of change (PSIC), across 4 core outcome domains, with the patient's global impression of change (PGIC)
- Follow-up
- POD 3
Methodological detailsexploratory analysis, multicentre
- Exploratory analysis
- Multicentre
Main finding
As reported in the abstract
PSICs vs PGIC (ordinal regression)
- Overall model pseudo-R2
- 0.55
- Relative domain contribution: pain intensity
- 55%
- Relative domain contribution: self-efficacy
- 19%
- Relative domain contribution: adverse events
- 15%
- Relative domain contribution: pain-related interference of physical functioning
- 10%
Observational data: associations, not effects.
Further findings
Baseline characteristics and satisfaction with pain management vs patient's global impression of change (PGIC) · POD 3
- Pain-related worrying and depression: no association with PGIC
- Anxiety, preoperative pain, opioid intake, low satisfaction with and wish for more treatment, low treatment agency, overall dissatisfaction: associated with less improvement
- Receiving information about treatment: associated with greater improvement on PGIC
Original publication
Associations of baseline characteristics, patient-reported outcomes, and satisfaction with pain therapy with the patient's global impression of change: a prospective cohort study. Br J Anaesth. Published 13 February 2026. doi:10.
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