Benefit of epidural analgesia for postoperative pain control after a Kasai Portoenterostomy: A ten‐year retrospective cohort study
Main finding · Total opioid requirement (morphine equivalents)Result — go to the resultDifference in mean opioid requirement 0.63 mg/kg 95% CI 0.32–0.94Authors' conclusion
In our cohort study, continuous thoracic epidural analgesia in patients undergoing a Kasai portoenterostomy was associated with lower postoperative opioid use.
Study context
- Population
- Infants with biliary atresia undergoing Kasai portoenterostomy, Children's Hospital of Philadelphia, 2009–2019
- Participants
- 91 infants
- Exposure
- Non-epidural vs Epidural
- Epiduraln = 63
- Outcome
- Postoperative systemic opioids in morphine equivalents (mg/kg)
- Follow-up
- POD 0 through 3
Methodological detailssingle-centre
- Single-centre
Main finding
Total opioid requirement (morphine equivalents) · first 72 h
Difference in mean opioid requirement
0.63 mg/kg
95% CI 0.32–0.94
By group
Non-epidural vs Epidural
difference in mean opioid requirement 0.63 mg/kg (95% CI 0.32–0.94)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Epidural | Non-epidural | Difference in proportion (95% CI) | P value | |
|---|---|---|---|---|---|
| Unplanned ICU admissions | 3.3% | 36% | 32.7% (13–52%) | P < 0.01 | |
| Postoperative oxygen requirement | 11.3% | 32.1% | 21% (2–40%) | P = 0.02 | |
| −50050100Difference (linear scale) |
Original publication
Benefit of epidural analgesia for postoperative pain control after a Kasai Portoenterostomy: A ten‐year retrospective cohort study. Paediatr Anaesth. Published 2 November 2022. doi:10.
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