Pain medicine

Beyond traditional therapies: a network meta-analysis on the treatment efficacy for chronic phantom limb pain

Reg Anesth Pain MedPublished Systematic review and network meta-analysis of randomised controlled trials

Pooled result · Pain improvementResult — go to the resultMean difference −2.9 points 95% CI −4.62 to −1.18

Authors' conclusion

The NMA suggests that neuromodulation using repetitive transcranial magnetic stimulation may be associated with significantly larger pain improvement for chronic PLP.

Study context

Population
Patients with chronic phantom limb pain (PLP)12 randomized controlled trials (RCTs)
Comparison
Repetitive transcranial magnetic stimulation vs Placebo/sham
Outcome
Pain score improvement
Methodological detailsPRISMA
  • PRISMA

Pooled result

Pain improvement

Mean difference

−2.9 points

95% CI −4.62 to −1.18

Repetitive transcranial magnetic stimulation vs Placebo/sham
mean difference −2.9 points (95% CI −4.62 to −1.18)

As reported in the abstract

Safety

OutcomeOR (95% CI)
Adverse event rateMorphine vs Placebo/sham · quality of evidence: low6.04 (2.26–16.12)

Original publication

Beyond traditional therapies: a network meta-analysis on the treatment efficacy for chronic phantom limb pain. Reg Anesth Pain Med. Published 21 February 2024. doi:10.1136/rapm-2023-105104

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