Neuroanesthesia & neurocritical care
Brain magnetic resonance imaging findings six months after critical COVID-19: A prospective cohort study
Authors' conclusion
Age and supplementary oxygen days were independently associated with CMBs; COVID-19 status showed no association. Accumulation of risk factors in the ICU group may explain the higher prevalence of CMBs.
Study context
- Population
- Patients 6 months after acute COVID-19 of differing severity and non-COVID-19 controls undergoing brain MRI
- Participants
- 69 / 46 / 46 / 53
- Exposure
- ICU-treated vs Ward-treated vs Home-isolated vs Non-COVID controls
- ICU-treatedn = 69
- Ward-treatedn = 46
- Home-isolatedn = 46
- Non-COVID controlsn = 53reference
- Outcome
- Long-term brain MRI findings (cerebral microbleeds)
- Follow-up
- Six months after acute COVID-19
Main finding
As reported in the abstract
Cerebral microbleeds (CMBs) · six months
- Age associated with cerebral microbleeds (CMBs) (multivariable analysis), OR
- 1.06 (95% CI 1.02-1.09)
- Supplementary oxygen days associated with CMBs (multivariable analysis), OR
- 1.07 (95% CI 1.02-1.13)
Observational data: associations, not effects.
Further findings
- Ischaemic infarctions · six months — ICU-treated
- 5.8%
Characteristics of patients with CMBs
- Patients with CMBs older
- P < 0.001
- Patients with CMBs had higher plasma NfL
- P = 0.003
- Patients with CMBs had more supplementary oxygen days
- P < 0.001
Distribution of CMBs
- ICU group showed prevalent distribution of CMBs in deep regions
Original publication
Brain magnetic resonance imaging findings six months after critical COVID-19: A prospective cohort study. J Crit Care. Published 19 December 2023. doi:10.
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