Perioperative medicine & outcomes
Changes in circulating extracellular vesicle cargo are associated with cognitive decline after major surgery: an observational case–control study
Authors' conclusion
Our findings highlight the impact of surgery on plasma- and CSF-derived EVs, particularly in patients with poor neurocognitive outcomes, indicating a potential role for EVs.
Study context
- Population
- Patients undergoing hip or knee replacement surgery
- Participants
- 12 patients
- Exposure
- Poor vs good neurocognitive outcomes at 3 months after surgery
- Poor neurocognitive outcomesn = 6
- Good neurocognitive outcomesn = 6reference
- Outcome
- Plasma- and CSF-derived EV cargo (microRNAome, proteome, complement C3)
- Follow-up
- Preoperative and 4, 8, 24, and 48 h postoperative
Main finding
As reported in the abstract
- Dysregulated EV microRNAs (miRNAs) exclusively in the poor neurocognitive outcomes group
- 8
Observational data: associations, not effects.
Further findings
Pathway analysis of EV target tissues
- Potential downregulation of proliferative pathways and activation of extracellular matrix and inflammatory response pathways
Original publication
Changes in circulating extracellular vesicle cargo are associated with cognitive decline after major surgery: an observational case–control study. Br J Anaesth. Published 18 October 2024. doi:10.
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