ICU sedation, delirium & recovery
Changes in nitric oxide inhibitors and mortality in critically ill patients: a cohort study
Main finding · 30-day all-cause mortality per daily twofold increase in ADMA days 1-3Result — go to the resultHazard ratio 0.45 95% CI 0.21–0.98Authors' conclusion
Increasing ADMA concentrations on days 1-3 are inversely associated with mortality, however not with the same strength as high ADMA or SDMA concentrations at admission.
Study context
- Population
- Adult critically ill Intensive Care Unit (ICU) patients, Copenhagen University Hospital - North Zealand567 with plasma samples days 1–5
- Participants
- 577 patients
- Exposure
- Change in nitric oxide (NO)-biomarkers days 1-3 and 30-day all-cause mortality
- Outcome
- 30-day all-cause mortality by change in NO-biomarker concentration days 1-3
- Follow-up
- 30 days
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
30-day all-cause mortality per daily twofold increase in ADMA days 1-3
Hazard ratio
0.45
95% CI 0.21–0.98
P = 0.046
Daily twofold increase in ADMA days 1-3
HR 0.45 (95% CI 0.21–0.98); P = 0.046
Per daily twofold increase in ADMA days, as printed
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| 30-day all-cause mortality per twofold increase in admission concentration (post-hoc)Twofold increase in ADMA at admission · post-hoc | 1.78 (1.24–2.57) | P = 0.0025 | |
| 30-day all-cause mortality per twofold increase in admission concentration (post-hoc)Twofold increase in SDMA at admission · post-hoc | 1.41 (1.05–1.90) | P = 0.024 | |
| 0.20.5125Hazard ratio (log scale) |
Plasma NO-biomarker concentrations days 1-5
- Asymmetric dimethylarginine (ADMA) and arginine increased days 1-5
- Symmetric dimethylarginine (SDMA) increased days 1-2, then decreased days 2-5
- Homoarginine unchanged days 1-3, slightly increased days 3-5
Original publication
Changes in nitric oxide inhibitors and mortality in critically ill patients: a cohort study. Ann Intensive Care. Published 27 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →