ICU sedation, delirium & recovery

Changes in Restricting Symptoms after Critical Illness among Community-Living Older Adults

Am J Respir Crit Care MedPublished Prospective longitudinal cohort study

Authors' conclusion

Restricting symptoms increase substantially after a critical illness before returning to baseline three months after hospital discharge.

Study context

Population
Community-living adults ⩾70 years old admitted to the ICU (1998–2018)
Participants
193 participants · 233 ICU admissions
Exposure
Six months after critical illness hospitalization vs baseline
Outcome
Occurrence and number of 15 restricting symptoms (leading to restricted activity)
Follow-up
Six months after hospital discharge
Methodological detailsmonthly interviews
  • Monthly interviews

Main finding

As reported in the abstract

Occurrence and number of restricting symptoms · six months after hospitalization
After discharge vs BaselineAdjusted rate ratio (95% CI)
Occurrence
3.1(2.1–4.6)
Number
3.3(2.1–5.3)

Observational data: associations, not effects.

Further findings

OutcomeAdjusted rate ratio (95% CI)
Occurrence and number of restricting symptoms, first month · first month after hospitalizationAfter discharge vs Baseline · occurrence5.3 (3.8–7.3)
Occurrence and number of restricting symptoms, first month · first month after hospitalizationAfter discharge vs Baseline · number5.4 (3.9–7.5)

Occurrence and number of restricting symptoms, first month · first month after hospitalization

Increases declined and became nonsignificant in the third month

Subgroups: sex, multimorbidity, individual- or neighborhood-level socioeconomic disadvantage (subgroup)

Increases in restricting symptoms did not differ significantly by subgroup

Original publication

Changes in Restricting Symptoms after Critical Illness among Community-Living Older Adults. Am J Respir Crit Care Med. Published 1 December 2023. doi:10.1164/rccm.202304-0693oc

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