Perioperative medicine & outcomes
Characteristics associated with effectiveness in postoperative delirium research: a systematic review of randomised controlled trials with meta-regression and meta-analysis
Authors' conclusion
The effectiveness of postoperative delirium trials varied based on the region of trial origin, the incidence of delirium, and the risk of bias.
Study context
- Population
- Randomised trials of interventions to reduce postoperative delirium
- Participants
- 201 eligible trials
- Comparison
- Trial characteristics associated with intervention effectiveness
- Outcome
- Trial characteristics associated with effectiveness estimated using ORs
Methodological detailsmultivariable meta-regression
- Multivariable meta-regression
Pooled result
As reported in the abstract
Region of trial origin
Each group vs chinaRatio of OR (95% CI)
USA/Canada89% higher OR, suggesting reduced effectiveness
1.89(1.45–2.45)
Europe/Australia/New Zealand67% higher OR
1.67(1.29–2.18)
- Effectiveness enhanced as postoperative delirium incidence increased (ratio of OR per 10% increase)
- 0.85; 0.79-0.92
- Concerns re deviations from intended interventions vs low risk: increased effectiveness (ratio of OR)
- 0.69; 0.53-0.90
Further pooled results
Pooled effectiveness vs usual care (meta-analysis)
- Certain interventions appeared to reduce postoperative delirium incidence in low-risk trials, low-to-moderate certainty; inconclusive
Original publication
Characteristics associated with effectiveness in postoperative delirium research: a systematic review of randomised controlled trials with meta-regression and meta-analysis. Br J Anaesth. Published 4 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →