Clinical Efficacy of Beta-1 Selective Beta-Blockers Versus Propranolol in Patients With Thyroid Storm: A Retrospective Cohort Study*
Main finding · In-hospital mortality (adjusted)Result — go to the resultOdds ratio 0.85 95% CI 0.57–1.26Authors' conclusion
In patients with thyroid storm, the choice between beta-1 selective beta-blockers and propranolol did not affect in-hospital mortality, regardless of the presence of acute heart failure.
Study context
- Population
- Patients hospitalised with thyroid storm, Diagnosis Procedure Combination database (Japan), April 2010–March 2022
- Participants
- 2,462 eligible patients
- Exposure
- Beta-1 selective beta-blockers vs propranolol
- Beta-1 selective beta-blockersn = 1,452
- Propranololn = 1,010reference
- Outcome
- In-hospital mortality (adjusted)
Methodological detailspropensity-score overlap weighting, national inpatient database
- Propensity-score overlap weighting
- National inpatient database
Main finding
As reported in the abstract
Odds ratio
0.85
95% CI 0.57–1.26
By group
Beta-1 selective beta-blockers vs Propranolol
OR 0.85 (95% CI 0.57–1.26)
Observational data: associations, not effects.
Further findings
Crude in-hospital mortality
In-hospital mortality, patients with acute HF (subgroup)
- No significant difference in in-hospital mortality
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Clinical Efficacy of Beta-1 Selective Beta-Blockers Versus Propranolol in Patients With Thyroid Storm: A Retrospective Cohort Study*. Crit Care Med. Published 29 March 2024. doi:10.
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