Neuroanesthesia & neurocritical care
Clinical Outcomes After Traumatic Brain Injury and Exposure to Extracranial Surgery: A Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) Study
Authors' conclusion
This study found that exposure to EC surgery and anesthesia was associated with adverse functional outcomes and impaired executive function after TBI.
Study context
- Population
- Adults ≥17 y admitted within 24 h of trauma with traumatic brain injury (TBI) (computed tomography (CT)- mTBI, CT+ mTBI, m/sTBI) or peripheral orthopedic injury, without cranial surgery, 18 US level I trauma centers, 2014–2018analyzed
- Participants
- 1,835 adults
- Comparison
- Extracranial (EC) surgery during index admission vs no surgery
- EC surgeryn = 486
- Nonsurgicaln = 1,349reference
- Primary endpoint
- Functional limitations (GOSE-ALL and GOSE-TBI) and neurocognitive outcomes
- Follow-up
- 2 weeks and 6 months after injury
Methodological detailsretrospective, multicentre (18 level I US trauma centers)
- Retrospective
- Multicentre (18 level I US trauma centers)
Primary result
As reported in the abstract
Functional and neurocognitive outcomes by TBI severity · 6 months
- m/sTBI
- B (GOSE-TBI), m/sTBI −1.11 (95% CI −1.53 to −0.68)
- CT+ mTBI
- B (GOSE-TBI), CT+ mTBI −0.39 (95% CI −0.77 to −0.01)
- m/sTBI
- B (Trail Making Test Part B), m/sTBI 30.1 (95% CI 11.9–48.2)
- CT+ mTBI
- B (Trail Making Test Part B), CT+ mTBI 26.3 (95% CI 11.3–41.2)
Original publication
Clinical Outcomes After Traumatic Brain Injury and Exposure to Extracranial Surgery: A TRACK-TBI Study. JAMA Surg. Published 1 March 2024. doi:10.
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