Perioperative medicine & outcomes
Clinical validation of an intra-abdominal pressure monitoring system by comparison with pneumoperitoneum pressure
Authors' conclusion
The IAP monitoring system underestimated the IAP set by the CO2-insufflator by approximately 1 mmHg. The wide limits of agreement warrant cautious interpretation. Overall, the IAP monitoring system showed reasonable accuracy and precision. The increase of several renal biomarkers during laparoscopy compared to baseline may reflect a direct effect of elevated IAP on the kidney.
Study context
- Population
- Patients undergoing laparoscopy at the University Medical Center Groningenpatients, 99 measurements performed between March 2025 and January 2026
- Participants
- 29 patients
- Exposure
- Intra-abdominal pressure (IAP) monitoring system compared to a reference standard, the CO2 insufflator, during laparoscopy
- Outcome
- Agreement between the IAP monitoring system and the CO2-insufflators (Bland-Altman, accounting for repeated measures)
Main finding
As reported in the abstract
Bias
−1.4 mmHg (95% CI (−1.96 - (−0.82))
Limits of agreement
- 5.96 mmHg and 3.2 mmHg
95% CI −6.8–3.99
Precision
2.3 mmHg
Observational data: associations, not effects.
Further findings
Renal biomarkers (KIM-1, TIMP-2, albumin/Cr ratio) · during laparoscopy compared to baseline
- Levels of KIM-1, TIMP-2 and albumin/Cr ratio increased during laparoscopy compared to baseline
Type of surgery
- Hemicolectomy
- One patient (3%)
- Endometriosis surgery
- 28 patients (97%)
Original publication
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