ICU sedation, delirium & recovery
Clinical Warburg effect in lymphoma patients admitted to intensive care unit
Main finding · 1-year mortalityResult — go to the resultHazard ratio 3.87 95% CI 2.13–7.02Authors' conclusion
CWE is associated with a higher tumor burden and increased 1-year mortality compared to patients without this condition.
Study context
- Population
- Patients with aggressive lymphoproliferative malignancies admitted to the ICU, January 2017–December 2022
- Participants
- 135 patients
- Exposure
- Clinical Warburg Effect (CWE) vs NW-HL vs NW-NL
- CWEn = 46
- Outcome
- Mortality
- Follow-up
- 1 year
Methodological detailsmultivariable analyses
- Multivariable analyses
Main finding
1-year mortality
Hazard ratio
3.87
95% CI 2.13–7.02
By group
CWE vs NW-NL
HR 3.87 (95% CI 2.13–7.02)
As reported in the abstract
- Overall 1-year deaths
- 72 (53%)
Observational data: associations, not effects.
Further findings
Other factors independently associated with 1-year mortality
| HR (95% CI) | ||
|---|---|---|
| Age | 1.02 (1.00–1.04) | |
| Total SOFA score at admission | 1.19 (1.12–1.25) | |
| 0.512Hazard ratio (log scale) |
Factors associated with CWE
| OR (95% CI) | ||
|---|---|---|
| Tumor lysis syndrome | 2.84 (1.14–7.42) | |
| Bone involvement | 3.58 (1.02–12.91) | |
| Total SOFA score at admission | 0.81 (0.69–0.91) | |
| Hypoglycemia at admission | 14.90 (5.42–47.18) | |
| 0.050.21520Odds ratio (log scale) |
Clinical characteristics of CWE
- CWE: higher proportion of Burkitt and T cell lymphomas, greater tumor burden, more frequent bone and cerebral involvement than other groups
Original publication
Clinical Warburg effect in lymphoma patients admitted to intensive care unit. Ann Intensive Care. Published 5 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →