Perioperative medicine & outcomes
Cognitive Deficits in Executive and Language Functions Predict Postoperative Delirium
Authors' conclusion
Impairment in the cognitive domains of executive function and language skills associated with memory, inhibition, and access speed seem to be particularly associated with the development of delirium after surgery in adults ≥65 years of age without apparent preoperative neurocognitive impairment.
Study context
- Population
- Patients ≥60 years without major neurocognitive disorders (dementia, Mini-Mental State Examination score ≤23) scheduled for cardiovascular surgery, Hamburg, Germanyincluded in the analysis
- Participants
- 541 patients
- Primary endpoint
- POD (delirium screening twice daily until postoperative day 5), predicted by preoperative neuropsychologic test performance
Methodological detailssingle-centre
- Single-centre
Primary result
As reported in the abstract
Predictors of POD (multiple logistic regression, adjusted for confounders)
Odds ratio (95% CI)
Low performance, Trail Making Test B/A
1.32(1.05–1.66)
Letter fluency
0.66(0.45–0.96)
- Delirium rate
- 15.6%
- AUC of final model to predict postoperative delirium (POD)
- 0.786
Original publication
Cognitive Deficits in Executive and Language Functions Predict Postoperative Delirium. J Cardiothorac Vasc Anesth. Published 7 September 2023. doi:10.
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